A Rapid-Patterning 3D Vessel-on-Chip for Imaging and Quantitatively Analyzing Cell–Cell Junction Phenotypes

A Rapid-Patterning 3D Vessel-on-Chip for Imaging and Quantitatively Analyzing Cell–Cell Junction Phenotypes

The blood-brain barrier (BBB) is a dynamic interface that regulates the molecular exchanges between the brain and peripheral blood. The permeability of the BBB is primarily regulated by the junction proteins on the brain endothelial cells. In vitro BBB models have shown great potential for the inves...

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Bibliographic Details
Main Authors: Li Yan, Cole W. Dwiggins, Udit Gupta, Kimberly M. Stroka
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Bioengineering
Subjects:
blood-brain barrier
3D vessel-on-chip
tight junctions
cell morphology
Online Access:https://www.mdpi.com/2306-5354/10/9/1080

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