Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells
New treatment strategies are required for ulcerative colitis. Here the authors show in mouse models that cholesterol sulfate, an endogenous active cholesterol derivative, contributes to the healing of the mucosal barrier by promoting cholesterol biosynthesis in colonic epithelial cells and exhibits...
Full description
Bibliographic Details
| Main Authors: |
Dongke Xu,
Ruijun Ma,
Yi Ju,
Xiaowei Song,
Baolin Niu,
Wenting Hong,
Rong Wang,
Qin Yang,
Zhi Zhao,
Yuchen Zhang,
Yufan Zheng,
Qianming Bai,
Mingfang Lv,
Ning Sun,
Xiaobo Li |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2022-07-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-022-32158-7
|
|---|