Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells
New treatment strategies are required for ulcerative colitis. Here the authors show in mouse models that cholesterol sulfate, an endogenous active cholesterol derivative, contributes to the healing of the mucosal barrier by promoting cholesterol biosynthesis in colonic epithelial cells and exhibits...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32158-7 |
| _version_ | 1818502782023368704 |
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| author | Dongke Xu Ruijun Ma Yi Ju Xiaowei Song Baolin Niu Wenting Hong Rong Wang Qin Yang Zhi Zhao Yuchen Zhang Yufan Zheng Qianming Bai Mingfang Lv Ning Sun Xiaobo Li |
| author_facet | Dongke Xu Ruijun Ma Yi Ju Xiaowei Song Baolin Niu Wenting Hong Rong Wang Qin Yang Zhi Zhao Yuchen Zhang Yufan Zheng Qianming Bai Mingfang Lv Ning Sun Xiaobo Li |
| author_sort | Dongke Xu |
| collection | DOAJ |
| description | New treatment strategies are required for ulcerative colitis. Here the authors show in mouse models that cholesterol sulfate, an endogenous active cholesterol derivative, contributes to the healing of the mucosal barrier by promoting cholesterol biosynthesis in colonic epithelial cells and exhibits therapeutic efficacy against ulcerative colitis. |
| first_indexed | 2024-12-10T21:15:01Z |
| format | Article |
| id | doaj.art-849554b1c12840069e894628571bfe01 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T21:15:01Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-849554b1c12840069e894628571bfe012022-12-22T01:33:20ZengNature PortfolioNature Communications2041-17232022-07-0113111710.1038/s41467-022-32158-7Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cellsDongke Xu0Ruijun Ma1Yi Ju2Xiaowei Song3Baolin Niu4Wenting Hong5Rong Wang6Qin Yang7Zhi Zhao8Yuchen Zhang9Yufan Zheng10Qianming Bai11Mingfang Lv12Ning Sun13Xiaobo Li14Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityCenter for Gastrointestinal Endoscopy, Shanxi Provincial People’s HospitalDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Chemistry, Fudan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityCenter for Gastrointestinal Endoscopy, Shanxi Provincial People’s HospitalDepartment of Pathology, Shanxi Provincial People’s HospitalDepartment of Medical Record and Statistics, Shanxi Provincial People’s HospitalDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Pathology, Fudan University Shanghai Cancer CentreDepartment of Immunology, School of Basic Medical Sciences, Fudan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan UniversityNew treatment strategies are required for ulcerative colitis. Here the authors show in mouse models that cholesterol sulfate, an endogenous active cholesterol derivative, contributes to the healing of the mucosal barrier by promoting cholesterol biosynthesis in colonic epithelial cells and exhibits therapeutic efficacy against ulcerative colitis.https://doi.org/10.1038/s41467-022-32158-7 |
| spellingShingle | Dongke Xu Ruijun Ma Yi Ju Xiaowei Song Baolin Niu Wenting Hong Rong Wang Qin Yang Zhi Zhao Yuchen Zhang Yufan Zheng Qianming Bai Mingfang Lv Ning Sun Xiaobo Li Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells Nature Communications |
| title | Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| title_full | Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| title_fullStr | Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| title_full_unstemmed | Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| title_short | Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| title_sort | cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells |
| url | https://doi.org/10.1038/s41467-022-32158-7 |
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