Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials
In order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in v...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1100 |
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| author | Fredric G. Svensson Vivek Anand Manivel Gulaim A. Seisenbaeva Vadim G. Kessler Bo Nilsson Kristina N. Ekdahl Karin Fromell |
| author_facet | Fredric G. Svensson Vivek Anand Manivel Gulaim A. Seisenbaeva Vadim G. Kessler Bo Nilsson Kristina N. Ekdahl Karin Fromell |
| author_sort | Fredric G. Svensson |
| collection | DOAJ |
| description | In order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in vitro human whole blood model. To our knowledge, this is the first study of the molecular interaction between hybrid nanotitania and blood proteins. Two of the hybrid materials prepared with 3 nm colloidal titania and 10 nm hydrothermally synthesized titania induced strong coagulation and platelet activation but negligible complement activation. Hence, they have great potential as a new dressing for promoting wound healing. Unlike the other two, the third hybrid material using molecular ammonium oxo-lactato titanate as a titania source inhibited platelet consumption, TAT generation, and complement activation, apparently via lowered pH at the surface interface. It is therefore suitable for applications where a passivating surface is desired, such as drug delivery systems and extracorporeal circuits. This opens the possibility for a tailored blood response through the surface functionalization of titania. |
| first_indexed | 2024-03-10T12:01:00Z |
| format | Article |
| id | doaj.art-8495aeb9f90643adb5da495b0700ee94 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T12:01:00Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-8495aeb9f90643adb5da495b0700ee942023-11-21T16:57:57ZengMDPI AGNanomaterials2079-49912021-04-01115110010.3390/nano11051100Hemocompatibility of Nanotitania-Nanocellulose Hybrid MaterialsFredric G. Svensson0Vivek Anand Manivel1Gulaim A. Seisenbaeva2Vadim G. Kessler3Bo Nilsson4Kristina N. Ekdahl5Karin Fromell6Department of Molecular Sciences, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-750 07 Uppsala, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, SwedenDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-750 07 Uppsala, SwedenDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-750 07 Uppsala, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, SwedenIn order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in vitro human whole blood model. To our knowledge, this is the first study of the molecular interaction between hybrid nanotitania and blood proteins. Two of the hybrid materials prepared with 3 nm colloidal titania and 10 nm hydrothermally synthesized titania induced strong coagulation and platelet activation but negligible complement activation. Hence, they have great potential as a new dressing for promoting wound healing. Unlike the other two, the third hybrid material using molecular ammonium oxo-lactato titanate as a titania source inhibited platelet consumption, TAT generation, and complement activation, apparently via lowered pH at the surface interface. It is therefore suitable for applications where a passivating surface is desired, such as drug delivery systems and extracorporeal circuits. This opens the possibility for a tailored blood response through the surface functionalization of titania.https://www.mdpi.com/2079-4991/11/5/1100nanocellulosetitaniacoagulationplateletscomplement systemcontact system |
| spellingShingle | Fredric G. Svensson Vivek Anand Manivel Gulaim A. Seisenbaeva Vadim G. Kessler Bo Nilsson Kristina N. Ekdahl Karin Fromell Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials Nanomaterials nanocellulose titania coagulation platelets complement system contact system |
| title | Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials |
| title_full | Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials |
| title_fullStr | Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials |
| title_full_unstemmed | Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials |
| title_short | Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials |
| title_sort | hemocompatibility of nanotitania nanocellulose hybrid materials |
| topic | nanocellulose titania coagulation platelets complement system contact system |
| url | https://www.mdpi.com/2079-4991/11/5/1100 |
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