Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of neuronal assemblies underlying learning and m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.687558/full |
| _version_ | 1818906067643400192 |
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| author | Eve Honoré Abdessattar Khlaifia Anthony Bosson Jean-Claude Lacaille |
| author_facet | Eve Honoré Abdessattar Khlaifia Anthony Bosson Jean-Claude Lacaille |
| author_sort | Eve Honoré |
| collection | DOAJ |
| description | A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of neuronal assemblies underlying learning and memory. Inhibitory interneurons provide more than a simple transitory inhibition of hippocampal principal cells (PCs). The synaptic plasticity of inhibitory neurons provides long-lasting changes in the hippocampal network and is a key component of memory formation. The dendrite targeting interneurons expressing the peptide somatostatin (SOM) are particularly interesting in this regard because they display unique long-lasting synaptic changes leading to metaplastic regulation of hippocampal networks. In this article, we examine the actions of the neuropeptide SOM on hippocampal cells, synaptic plasticity, learning, and memory. We address the different subtypes of hippocampal SOM interneurons. We describe the long-term synaptic plasticity that takes place at the excitatory synapses of SOM interneurons, its singular induction and expression mechanisms, as well as the consequences of these changes on the hippocampal network, learning, and memory. We also review evidence that astrocytes provide cell-specific dynamic regulation of inhibition of PC dendrites by SOM interneurons. Finally, we cover how, in mouse models of Alzheimer’s disease (AD), dysfunction of plasticity of SOM interneuron excitatory synapses may also contribute to cognitive impairments in brain disorders. |
| first_indexed | 2024-12-19T21:33:20Z |
| format | Article |
| id | doaj.art-8495f8f5651f4fcf8b0467f124475c87 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-19T21:33:20Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-8495f8f5651f4fcf8b0467f124475c872022-12-21T20:04:51ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102021-06-011510.3389/fncir.2021.687558687558Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and MemoryEve HonoréAbdessattar KhlaifiaAnthony BossonJean-Claude LacailleA distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of neuronal assemblies underlying learning and memory. Inhibitory interneurons provide more than a simple transitory inhibition of hippocampal principal cells (PCs). The synaptic plasticity of inhibitory neurons provides long-lasting changes in the hippocampal network and is a key component of memory formation. The dendrite targeting interneurons expressing the peptide somatostatin (SOM) are particularly interesting in this regard because they display unique long-lasting synaptic changes leading to metaplastic regulation of hippocampal networks. In this article, we examine the actions of the neuropeptide SOM on hippocampal cells, synaptic plasticity, learning, and memory. We address the different subtypes of hippocampal SOM interneurons. We describe the long-term synaptic plasticity that takes place at the excitatory synapses of SOM interneurons, its singular induction and expression mechanisms, as well as the consequences of these changes on the hippocampal network, learning, and memory. We also review evidence that astrocytes provide cell-specific dynamic regulation of inhibition of PC dendrites by SOM interneurons. Finally, we cover how, in mouse models of Alzheimer’s disease (AD), dysfunction of plasticity of SOM interneuron excitatory synapses may also contribute to cognitive impairments in brain disorders.https://www.frontiersin.org/articles/10.3389/fncir.2021.687558/fullsomatostatininhibitory interneuronhippocampusnetwork metaplasticitylong-term potentiationspatial and contextual memory |
| spellingShingle | Eve Honoré Abdessattar Khlaifia Anthony Bosson Jean-Claude Lacaille Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory Frontiers in Neural Circuits somatostatin inhibitory interneuron hippocampus network metaplasticity long-term potentiation spatial and contextual memory |
| title | Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory |
| title_full | Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory |
| title_fullStr | Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory |
| title_full_unstemmed | Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory |
| title_short | Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory |
| title_sort | hippocampal somatostatin interneurons long term synaptic plasticity and memory |
| topic | somatostatin inhibitory interneuron hippocampus network metaplasticity long-term potentiation spatial and contextual memory |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.687558/full |
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