Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy
mTOR inhibitors have demonstrated remarkable anti-tumor activity in experimental models, mainly by reducing cancer cell growth and tumor angiogenesis. Their use in cancer patients as monotherapy has, however, generated only limited benefits, increasing median overall survival by only a few months. L...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/9/11/152 |
| _version_ | 1797720279200301056 |
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| author | Seraina Faes Tania Santoro Nicolas Demartines Olivier Dormond |
| author_facet | Seraina Faes Tania Santoro Nicolas Demartines Olivier Dormond |
| author_sort | Seraina Faes |
| collection | DOAJ |
| description | mTOR inhibitors have demonstrated remarkable anti-tumor activity in experimental models, mainly by reducing cancer cell growth and tumor angiogenesis. Their use in cancer patients as monotherapy has, however, generated only limited benefits, increasing median overall survival by only a few months. Likewise, in other targeted therapies, cancer cells develop resistance mechanisms to overcome mTOR inhibition. Hence, novel therapeutic strategies have to be designed to increase the efficacy of mTOR inhibitors in cancer. In this review, we discuss the present and future relevance of mTOR inhibitors in cancer therapy by focusing on their effects on tumor angiogenesis. |
| first_indexed | 2024-03-12T09:18:07Z |
| format | Article |
| id | doaj.art-84970b2c245b4c228f9ee00bbbe868f2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:18:07Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-84970b2c245b4c228f9ee00bbbe868f22023-09-02T14:44:05ZengMDPI AGCancers2072-66942017-11-0191115210.3390/cancers9110152cancers9110152Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer TherapySeraina Faes0Tania Santoro1Nicolas Demartines2Olivier Dormond3Department of Visceral Surgery, Lausanne University Hospital, Pavillon 4, avenue de Beaumont, 1011 Lausanne, SwitzerlandDepartment of Visceral Surgery, Lausanne University Hospital, Pavillon 4, avenue de Beaumont, 1011 Lausanne, SwitzerlandDepartment of Visceral Surgery, Lausanne University Hospital, Pavillon 4, avenue de Beaumont, 1011 Lausanne, SwitzerlandDepartment of Visceral Surgery, Lausanne University Hospital, Pavillon 4, avenue de Beaumont, 1011 Lausanne, SwitzerlandmTOR inhibitors have demonstrated remarkable anti-tumor activity in experimental models, mainly by reducing cancer cell growth and tumor angiogenesis. Their use in cancer patients as monotherapy has, however, generated only limited benefits, increasing median overall survival by only a few months. Likewise, in other targeted therapies, cancer cells develop resistance mechanisms to overcome mTOR inhibition. Hence, novel therapeutic strategies have to be designed to increase the efficacy of mTOR inhibitors in cancer. In this review, we discuss the present and future relevance of mTOR inhibitors in cancer therapy by focusing on their effects on tumor angiogenesis.https://www.mdpi.com/2072-6694/9/11/152mTORtumor angiogenesisrapalogscancerendothelial cell |
| spellingShingle | Seraina Faes Tania Santoro Nicolas Demartines Olivier Dormond Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy Cancers mTOR tumor angiogenesis rapalogs cancer endothelial cell |
| title | Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy |
| title_full | Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy |
| title_fullStr | Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy |
| title_full_unstemmed | Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy |
| title_short | Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy |
| title_sort | evolving significance and future relevance of anti angiogenic activity of mtor inhibitors in cancer therapy |
| topic | mTOR tumor angiogenesis rapalogs cancer endothelial cell |
| url | https://www.mdpi.com/2072-6694/9/11/152 |
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