Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
<p>Abstract</p> <p>Background</p> <p>High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioacti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: |
| _version_ | 1823994239625723904 |
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| author | Liu Nana Ma Yanmin Wang Shuyu Zhang Xiaowei Zhang Qiufang Zhang Xue Fu Li Qiao Jie |
| author_facet | Liu Nana Ma Yanmin Wang Shuyu Zhang Xiaowei Zhang Qiufang Zhang Xue Fu Li Qiao Jie |
| author_sort | Liu Nana |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.</p> <p>Methods</p> <p>315 PCOS women and 212 controls were screened for the gene variants of <it>LH</it> G1052A and <it>LHR</it> rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).</p> <p>Results</p> <p>PCOS patients had significantly more A allele frequency of <it>LH</it> G1052A mutations than controls (p=0.001). Within PCOS group, carriers of <it>LH</it> 1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with <it>LHR</it> rs61996318 polymorphisms. A new <it>LHR</it> single nucleotide polymorphism (SNP) was found without clear association with PCOS.</p> <p>Conclusions</p> <p>Results suggested <it>LH</it> G1052A mutation might influence PCOS susceptibility and phenotypes.</p> |
| first_indexed | 2024-12-18T16:31:42Z |
| format | Article |
| id | doaj.art-8498e9fb2acc4e42b44d0a837c4dacae |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-18T16:31:42Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-8498e9fb2acc4e42b44d0a837c4dacae2022-12-21T21:01:26ZengBMCReproductive Biology and Endocrinology1477-78272012-04-011013610.1186/1477-7827-10-36Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndromeLiu NanaMa YanminWang ShuyuZhang XiaoweiZhang QiufangZhang XueFu LiQiao Jie<p>Abstract</p> <p>Background</p> <p>High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.</p> <p>Methods</p> <p>315 PCOS women and 212 controls were screened for the gene variants of <it>LH</it> G1052A and <it>LHR</it> rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).</p> <p>Results</p> <p>PCOS patients had significantly more A allele frequency of <it>LH</it> G1052A mutations than controls (p=0.001). Within PCOS group, carriers of <it>LH</it> 1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with <it>LHR</it> rs61996318 polymorphisms. A new <it>LHR</it> single nucleotide polymorphism (SNP) was found without clear association with PCOS.</p> <p>Conclusions</p> <p>Results suggested <it>LH</it> G1052A mutation might influence PCOS susceptibility and phenotypes.</p>Luteinizing hormoneLuteinizing hormone receptorPolycystic ovary syndromeGene polymorphism |
| spellingShingle | Liu Nana Ma Yanmin Wang Shuyu Zhang Xiaowei Zhang Qiufang Zhang Xue Fu Li Qiao Jie Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome Reproductive Biology and Endocrinology Luteinizing hormone Luteinizing hormone receptor Polycystic ovary syndrome Gene polymorphism |
| title | Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome |
| title_full | Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome |
| title_fullStr | Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome |
| title_full_unstemmed | Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome |
| title_short | Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome |
| title_sort | association of the genetic variants of luteinizing hormone luteinizing hormone receptor and polycystic ovary syndrome |
| topic | Luteinizing hormone Luteinizing hormone receptor Polycystic ovary syndrome Gene polymorphism |
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