The Issue of Misidentification of Kojic Acid with Flufuran in <i>Aspergillus flavus</i>

In the course of investigations on the complex phenomenon of bee decline, <i>Aspergillus flavus</i> was isolated from the haemocoel of worker bees. Observations on the metabolomic profile of this strain showed kojic acid to be the dominant product in cultures on Czapek-Dox broth. However...

Full description

Bibliographic Details
Main Authors: Marina DellaGreca, Gaetano De Tommaso, Maria Michela Salvatore, Rosario Nicoletti, Andrea Becchimanzi, Mauro Iuliano, Anna Andolfi
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/9/1709
Description
Summary:In the course of investigations on the complex phenomenon of bee decline, <i>Aspergillus flavus</i> was isolated from the haemocoel of worker bees. Observations on the metabolomic profile of this strain showed kojic acid to be the dominant product in cultures on Czapek-Dox broth. However, an accurate review of papers documenting secondary metabolite production in <i>A. flavus</i> also showed that an isomer of kojic acid, identified as 5-(hydroxymethyl)-furan-3-carboxylic acid and named flufuran is reported from this species. The spectroscopic data of kojic acid were almost identical to those reported in the literature for flufuran. This motivated a comparative study of commercial kojic acid and 5-(hydroxymethyl)-furan-3-carboxylic acid, highlighting some differences, for example in the <sup>13</sup>C-NMR and UV spectra for the two compounds, indicating that misidentification of the kojic acid as 5-(hydroxymethyl)-furan-3-carboxylic acid has occurred in the past.
ISSN:1420-3049