Memantine inhibits 6-OHDA-induced apoptosis PC12 cells via the Nurr77 and caspase pathway

Memantine inhibits 6-OHDA-induced apoptosis PC12 cells via the Nurr77 and caspase pathway

Objective: To investigate the effect of memantine on Parkinson’s disease cell models. Methods: Parkinson’s disease cell models were established using PC12 cells incubated with 6-hydroxydopamine (6-OHDA). Flow cytometry and microscopy were used to investigate the apoptotic process and the percentage...

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Bibliographic Details
Main Authors: Wei Wu, Rui Wang, Yong-Mei Fu, Jie Zhou, Hai-Chao Huang, Wei-Wang Gu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
parkinson’s disease
6-ohda
nur77
memantine
apoptosis
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=14;spage=59;epage=68;aulast=Wu

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