Enhanced anti-tumor effect of a gene gun-delivered DNA vaccine encoding the human papillomavirus type 16 oncoproteins genetically fused to the herpes simplex virus glycoprotein D

Enhanced anti-tumor effect of a gene gun-delivered DNA vaccine encoding the human papillomavirus type 16 oncoproteins genetically fused to the herpes simplex virus glycoprotein D

Anti-cancer DNA vaccines have attracted growing interest as a simple and non-invasive method for both the treatment and prevention of tumors induced by human papillomaviruses. Nonetheless, the low immunogenicity of parenterally administered vaccines, particularly regarding the activation of cytotoxi...

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Bibliographic Details
Main Authors: M.O. Diniz, L.C.S. Ferreira
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Gene gun
DNA vaccine
HPV-16
Anti-cancer vaccine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500007&lng=en&tlng=en

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