Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates
Summary: Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has signi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223018552 |
| _version_ | 1797647897872826368 |
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| author | Zhiwen Fu Chen Gao Tingting Wu Lulu Wang Shijun Li Yu Zhang Chen Shi |
| author_facet | Zhiwen Fu Chen Gao Tingting Wu Lulu Wang Shijun Li Yu Zhang Chen Shi |
| author_sort | Zhiwen Fu |
| collection | DOAJ |
| description | Summary: Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs incorporating MMAE as payloads. Considering the increasing global use of MMAE-based ADCs, it is imperative to provide an inclusive overview of diagnostic and management strategies for this adverse event. In this review, we examine current information and what future research directions are required to better understand and manage this type of clinical challenge. |
| first_indexed | 2024-03-11T15:23:14Z |
| format | Article |
| id | doaj.art-849d6620e60546ceab03f1a5732694e6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-11T15:23:14Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-849d6620e60546ceab03f1a5732694e62023-10-28T05:08:24ZengElsevieriScience2589-00422023-10-012610107778Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugatesZhiwen Fu0Chen Gao1Tingting Wu2Lulu Wang3Shijun Li4Yu Zhang5Chen Shi6Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, China; Corresponding authorDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430000, China; Corresponding authorSummary: Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs incorporating MMAE as payloads. Considering the increasing global use of MMAE-based ADCs, it is imperative to provide an inclusive overview of diagnostic and management strategies for this adverse event. In this review, we examine current information and what future research directions are required to better understand and manage this type of clinical challenge.http://www.sciencedirect.com/science/article/pii/S2589004223018552Health sciencesMedicineToxicologyOncologyCancer systems biologyCancer |
| spellingShingle | Zhiwen Fu Chen Gao Tingting Wu Lulu Wang Shijun Li Yu Zhang Chen Shi Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates iScience Health sciences Medicine Toxicology Oncology Cancer systems biology Cancer |
| title | Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates |
| title_full | Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates |
| title_fullStr | Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates |
| title_full_unstemmed | Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates |
| title_short | Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates |
| title_sort | peripheral neuropathy associated with monomethyl auristatin e based antibody drug conjugates |
| topic | Health sciences Medicine Toxicology Oncology Cancer systems biology Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223018552 |
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