Internet-based survey intervention improves adherence to methotrexate among psoriasis patients

Background While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digita...

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Main Authors: Abigail Cline, Emily L. Unrue, Leah A. Cardwell, Hossein Alinia, Rechelle Tull, Steven R. Feldman, William W. Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-08-01
Series:Journal of Dermatological Treatment
Subjects:
Online Access:http://dx.doi.org/10.1080/09546634.2022.2071821
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author Abigail Cline
Emily L. Unrue
Leah A. Cardwell
Hossein Alinia
Rechelle Tull
Steven R. Feldman
William W. Huang
author_facet Abigail Cline
Emily L. Unrue
Leah A. Cardwell
Hossein Alinia
Rechelle Tull
Steven R. Feldman
William W. Huang
author_sort Abigail Cline
collection DOAJ
description Background While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digital intervention improved adherence to oral methotrexate as measured by electronic monitoring. Methods Twenty-nine patients were randomized to receive either weekly digital interventions assessing treatment adherence or no intervention for 24 weeks. Patients received medication bottles with electronic monitoring, and returned at weeks 4, 12, and 24 to evaluate disease severity. Results The intervention group took methotrexate correctly 77.1% of the weeks observed compared to the control group which averaged 64.5%. More intervention patients took methotrexate as directed compared to the control group (78.3% vs 64.2%, p < 0.0001). Patients were most adherent around follow-up visits, with 100% of digital intervention patients and 80% of control patients taking methotrexate correctly during the week of a follow-up visit (p = 0.02). The digital intervention did not significantly improve disease severity in the intervention group compared to the nonintervention group. Conclusions Low cost, scalable digital interventions may have the potential to increase psoriasis patient adherence to methotrexate, although the mechanism for the improvement is not yet well defined.
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spelling doaj.art-849dfa1d7049409a8029c985136cbb4e2023-09-15T14:28:52ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-08-013362784278910.1080/09546634.2022.20718212071821Internet-based survey intervention improves adherence to methotrexate among psoriasis patientsAbigail Cline0Emily L. Unrue1Leah A. Cardwell2Hossein Alinia3Rechelle Tull4Steven R. Feldman5William W. Huang6Center for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineBackground While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digital intervention improved adherence to oral methotrexate as measured by electronic monitoring. Methods Twenty-nine patients were randomized to receive either weekly digital interventions assessing treatment adherence or no intervention for 24 weeks. Patients received medication bottles with electronic monitoring, and returned at weeks 4, 12, and 24 to evaluate disease severity. Results The intervention group took methotrexate correctly 77.1% of the weeks observed compared to the control group which averaged 64.5%. More intervention patients took methotrexate as directed compared to the control group (78.3% vs 64.2%, p < 0.0001). Patients were most adherent around follow-up visits, with 100% of digital intervention patients and 80% of control patients taking methotrexate correctly during the week of a follow-up visit (p = 0.02). The digital intervention did not significantly improve disease severity in the intervention group compared to the nonintervention group. Conclusions Low cost, scalable digital interventions may have the potential to increase psoriasis patient adherence to methotrexate, although the mechanism for the improvement is not yet well defined.http://dx.doi.org/10.1080/09546634.2022.2071821adherencemethotrexatepsoriasisclinical researchsystemic medication
spellingShingle Abigail Cline
Emily L. Unrue
Leah A. Cardwell
Hossein Alinia
Rechelle Tull
Steven R. Feldman
William W. Huang
Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
Journal of Dermatological Treatment
adherence
methotrexate
psoriasis
clinical research
systemic medication
title Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
title_full Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
title_fullStr Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
title_full_unstemmed Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
title_short Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
title_sort internet based survey intervention improves adherence to methotrexate among psoriasis patients
topic adherence
methotrexate
psoriasis
clinical research
systemic medication
url http://dx.doi.org/10.1080/09546634.2022.2071821
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