Internet-based survey intervention improves adherence to methotrexate among psoriasis patients
Background While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digita...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2022-08-01
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Series: | Journal of Dermatological Treatment |
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Online Access: | http://dx.doi.org/10.1080/09546634.2022.2071821 |
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author | Abigail Cline Emily L. Unrue Leah A. Cardwell Hossein Alinia Rechelle Tull Steven R. Feldman William W. Huang |
author_facet | Abigail Cline Emily L. Unrue Leah A. Cardwell Hossein Alinia Rechelle Tull Steven R. Feldman William W. Huang |
author_sort | Abigail Cline |
collection | DOAJ |
description | Background While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digital intervention improved adherence to oral methotrexate as measured by electronic monitoring. Methods Twenty-nine patients were randomized to receive either weekly digital interventions assessing treatment adherence or no intervention for 24 weeks. Patients received medication bottles with electronic monitoring, and returned at weeks 4, 12, and 24 to evaluate disease severity. Results The intervention group took methotrexate correctly 77.1% of the weeks observed compared to the control group which averaged 64.5%. More intervention patients took methotrexate as directed compared to the control group (78.3% vs 64.2%, p < 0.0001). Patients were most adherent around follow-up visits, with 100% of digital intervention patients and 80% of control patients taking methotrexate correctly during the week of a follow-up visit (p = 0.02). The digital intervention did not significantly improve disease severity in the intervention group compared to the nonintervention group. Conclusions Low cost, scalable digital interventions may have the potential to increase psoriasis patient adherence to methotrexate, although the mechanism for the improvement is not yet well defined. |
first_indexed | 2024-03-12T00:15:01Z |
format | Article |
id | doaj.art-849dfa1d7049409a8029c985136cbb4e |
institution | Directory Open Access Journal |
issn | 0954-6634 1471-1753 |
language | English |
last_indexed | 2024-03-12T00:15:01Z |
publishDate | 2022-08-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Journal of Dermatological Treatment |
spelling | doaj.art-849dfa1d7049409a8029c985136cbb4e2023-09-15T14:28:52ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-08-013362784278910.1080/09546634.2022.20718212071821Internet-based survey intervention improves adherence to methotrexate among psoriasis patientsAbigail Cline0Emily L. Unrue1Leah A. Cardwell2Hossein Alinia3Rechelle Tull4Steven R. Feldman5William W. Huang6Center for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineCenter for Dermatology Research, Department of Dermatology, Wake Forest School of MedicineBackground While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective The aim of this study was to evaluate whether a digital intervention improved adherence to oral methotrexate as measured by electronic monitoring. Methods Twenty-nine patients were randomized to receive either weekly digital interventions assessing treatment adherence or no intervention for 24 weeks. Patients received medication bottles with electronic monitoring, and returned at weeks 4, 12, and 24 to evaluate disease severity. Results The intervention group took methotrexate correctly 77.1% of the weeks observed compared to the control group which averaged 64.5%. More intervention patients took methotrexate as directed compared to the control group (78.3% vs 64.2%, p < 0.0001). Patients were most adherent around follow-up visits, with 100% of digital intervention patients and 80% of control patients taking methotrexate correctly during the week of a follow-up visit (p = 0.02). The digital intervention did not significantly improve disease severity in the intervention group compared to the nonintervention group. Conclusions Low cost, scalable digital interventions may have the potential to increase psoriasis patient adherence to methotrexate, although the mechanism for the improvement is not yet well defined.http://dx.doi.org/10.1080/09546634.2022.2071821adherencemethotrexatepsoriasisclinical researchsystemic medication |
spellingShingle | Abigail Cline Emily L. Unrue Leah A. Cardwell Hossein Alinia Rechelle Tull Steven R. Feldman William W. Huang Internet-based survey intervention improves adherence to methotrexate among psoriasis patients Journal of Dermatological Treatment adherence methotrexate psoriasis clinical research systemic medication |
title | Internet-based survey intervention improves adherence to methotrexate among psoriasis patients |
title_full | Internet-based survey intervention improves adherence to methotrexate among psoriasis patients |
title_fullStr | Internet-based survey intervention improves adherence to methotrexate among psoriasis patients |
title_full_unstemmed | Internet-based survey intervention improves adherence to methotrexate among psoriasis patients |
title_short | Internet-based survey intervention improves adherence to methotrexate among psoriasis patients |
title_sort | internet based survey intervention improves adherence to methotrexate among psoriasis patients |
topic | adherence methotrexate psoriasis clinical research systemic medication |
url | http://dx.doi.org/10.1080/09546634.2022.2071821 |
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