Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with resp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.765044/full |
| _version_ | 1818990485626159104 |
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| author | Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao |
| author_facet | Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao |
| author_sort | Ziwen Zhong |
| collection | DOAJ |
| description | B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA+ cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers. |
| first_indexed | 2024-12-20T19:55:07Z |
| format | Article |
| id | doaj.art-849ea2bc75c440928c6a1581b0e8b6b3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T19:55:07Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-849ea2bc75c440928c6a1581b0e8b6b32022-12-21T19:28:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.765044765044Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its TriggersZiwen Zhong0Ziwen Zhong1Ke Nan2Meilin Weng3Ying Yue4Wenchang Zhou5Zhiqiang Wang6Yiwei Chu7Yiwei Chu8Ronghua Liu9Changhong Miao10Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaShanghai Fifth People’s Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaShanghai Fifth People’s Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaB cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA+ cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.https://www.frontiersin.org/articles/10.3389/fimmu.2021.765044/fullB cellsplasma cellsimmunoglobulin Atumor immunityclass switching |
| spellingShingle | Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers Frontiers in Immunology B cells plasma cells immunoglobulin A tumor immunity class switching |
| title | Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers |
| title_full | Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers |
| title_fullStr | Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers |
| title_full_unstemmed | Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers |
| title_short | Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers |
| title_sort | pro and anti effects of immunoglobulin a producing b cell in tumors and its triggers |
| topic | B cells plasma cells immunoglobulin A tumor immunity class switching |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.765044/full |
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