Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain
Abstract Introduction Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP) and to explore factors associated to HRQoL. Patients and methods In...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-019-1841-y |
| _version_ | 1818510605736214528 |
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| author | Déborah Puyraimond-Zemmour Benjamin Granger Anna Molto Cécile Gaujoux-Viala Francis Guillemin Adeline Ruyssen-Witrand Maxime Dougados Bruno Fautrel Laure Gossec |
| author_facet | Déborah Puyraimond-Zemmour Benjamin Granger Anna Molto Cécile Gaujoux-Viala Francis Guillemin Adeline Ruyssen-Witrand Maxime Dougados Bruno Fautrel Laure Gossec |
| author_sort | Déborah Puyraimond-Zemmour |
| collection | DOAJ |
| description | Abstract Introduction Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP) and to explore factors associated to HRQoL. Patients and methods In 2 prospective observational French cohorts (ESPOIR for EA patients and DESIR for early IBP patients), HRQoL was assessed regularly over 5–8 years, using the SF36 physical and mental composite scores (PCS and MCS, range 0–100). Disease activity was assessed by DAS28-ESR and ASDAS-CRP. Univariate and multivariate linear mixed-effect models and trajectory-based mapping were applied. Results In all, 1347 patients (701 EA and 646 early IBP) were analysed: mean age 48.4 ± 12.2 and 33.9 ± 8.7 years respectively; mean disease duration 3.4 ± 1.7 and 18.2 ± 10.8 months; and 76.3% and 55.0% females. At baseline, in EA, mean PCS and MCS were respectively 40.2 ± 9.1 and 40.4 ± 11.2 and, in early IBP, were respectively 38.5 ± 8.5 and 39.8 ± 10.9. Over follow-up, HRQoL mean levels improved mostly over the first 6 months (p < 0.001). Two trajectories were evidenced in both diseases. The ‘good HRQoL’ trajectory groups, i.e. 54–61% of patients, reached levels of HRQoL close to population norms. DAS28-ESR and ASDAS-CRP over time were related to PCS (range of explained variance 9–43%, p < 0.001 in the mixed models) but not to MCS. Conclusion HRQoL was altered similarly for both physical and mental aspects in EA and early IBP. Disease activity only partly explained HRQoL: the drivers of HRQoL should be further explored. |
| first_indexed | 2024-12-10T23:22:17Z |
| format | Article |
| id | doaj.art-849ebf8540da49579f9c19d895ee275d |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-10T23:22:17Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-849ebf8540da49579f9c19d895ee275d2022-12-22T01:29:41ZengBMCArthritis Research & Therapy1478-63622019-02-0121111110.1186/s13075-019-1841-ySimilar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back painDéborah Puyraimond-Zemmour0Benjamin Granger1Anna Molto2Cécile Gaujoux-Viala3Francis Guillemin4Adeline Ruyssen-Witrand5Maxime Dougados6Bruno Fautrel7Laure Gossec8Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS)Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS)Paris Descartes University, Department of Rheumatology- HopitalCochinNîmes University Hospital, Department of Rheumatology, EA 2415, University of MontpellierUniversité de Lorraine, EA 4360 APEMAC and Inserm CIC, 1433 Epidémiologie clinique, CHRU de BraboisCHU de Toulouse, Hôpital Pierre-Paul RiquetParis Descartes University, Department of Rheumatology- HopitalCochinSorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS)Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS)Abstract Introduction Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP) and to explore factors associated to HRQoL. Patients and methods In 2 prospective observational French cohorts (ESPOIR for EA patients and DESIR for early IBP patients), HRQoL was assessed regularly over 5–8 years, using the SF36 physical and mental composite scores (PCS and MCS, range 0–100). Disease activity was assessed by DAS28-ESR and ASDAS-CRP. Univariate and multivariate linear mixed-effect models and trajectory-based mapping were applied. Results In all, 1347 patients (701 EA and 646 early IBP) were analysed: mean age 48.4 ± 12.2 and 33.9 ± 8.7 years respectively; mean disease duration 3.4 ± 1.7 and 18.2 ± 10.8 months; and 76.3% and 55.0% females. At baseline, in EA, mean PCS and MCS were respectively 40.2 ± 9.1 and 40.4 ± 11.2 and, in early IBP, were respectively 38.5 ± 8.5 and 39.8 ± 10.9. Over follow-up, HRQoL mean levels improved mostly over the first 6 months (p < 0.001). Two trajectories were evidenced in both diseases. The ‘good HRQoL’ trajectory groups, i.e. 54–61% of patients, reached levels of HRQoL close to population norms. DAS28-ESR and ASDAS-CRP over time were related to PCS (range of explained variance 9–43%, p < 0.001 in the mixed models) but not to MCS. Conclusion HRQoL was altered similarly for both physical and mental aspects in EA and early IBP. Disease activity only partly explained HRQoL: the drivers of HRQoL should be further explored.http://link.springer.com/article/10.1186/s13075-019-1841-yQuality of lifeRheumatoid arthritisAxial spondyloarthritisPatient outcomes assessmentEarly arthritisEarly inflammatory back pain |
| spellingShingle | Déborah Puyraimond-Zemmour Benjamin Granger Anna Molto Cécile Gaujoux-Viala Francis Guillemin Adeline Ruyssen-Witrand Maxime Dougados Bruno Fautrel Laure Gossec Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain Arthritis Research & Therapy Quality of life Rheumatoid arthritis Axial spondyloarthritis Patient outcomes assessment Early arthritis Early inflammatory back pain |
| title | Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| title_full | Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| title_fullStr | Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| title_full_unstemmed | Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| title_short | Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| title_sort | similar alteration for mental and physical aspects in health related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain |
| topic | Quality of life Rheumatoid arthritis Axial spondyloarthritis Patient outcomes assessment Early arthritis Early inflammatory back pain |
| url | http://link.springer.com/article/10.1186/s13075-019-1841-y |
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