Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
<h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392160/?tool=EBI |
| _version_ | 1828939898898350080 |
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| author | Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy |
| author_facet | Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy |
| author_sort | Salvatore Sotgia |
| collection | DOAJ |
| description | <h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.<h4>Methods</h4>Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study.<h4>Results</h4>Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = -0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = -0.13; P = 0.0063).<h4>Conclusions</h4>A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration. |
| first_indexed | 2024-12-14T03:10:04Z |
| format | Article |
| id | doaj.art-84a13ebc515a46c884ff0b6b4c1cdc5f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T03:10:04Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-84a13ebc515a46c884ff0b6b4c1cdc5f2022-12-21T23:19:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8491810.1371/journal.pone.0084918Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.Salvatore SotgiaAngelo ZinelluArduino A MangoniGianfranco PintusJohn AttiaCiriaco CarruMark McEvoy<h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.<h4>Methods</h4>Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study.<h4>Results</h4>Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = -0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = -0.13; P = 0.0063).<h4>Conclusions</h4>A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392160/?tool=EBI |
| spellingShingle | Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. PLoS ONE |
| title | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. |
| title_full | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. |
| title_fullStr | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. |
| title_full_unstemmed | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. |
| title_short | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. |
| title_sort | clinical and biochemical correlates of serum l ergothioneine concentrations in community dwelling middle aged and older adults |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392160/?tool=EBI |
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