Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention
Stroke is a leading cause of death worldwide. Vascular calcification (VC), defined as deposition of calcium-phosphate complexes in the vessels, is considered as the characteristic of vascular aging. Calcifications at different vessel layers have different implications. Intimal calcification is close...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.845215/full |
| _version_ | 1828845019780349952 |
|---|---|
| author | Xiang Wang Xiang Wang Xinghang Chen Xinghang Chen Zhuohui Chen Zhuohui Chen Mengqi Zhang Mengqi Zhang |
| author_facet | Xiang Wang Xiang Wang Xinghang Chen Xinghang Chen Zhuohui Chen Zhuohui Chen Mengqi Zhang Mengqi Zhang |
| author_sort | Xiang Wang |
| collection | DOAJ |
| description | Stroke is a leading cause of death worldwide. Vascular calcification (VC), defined as deposition of calcium-phosphate complexes in the vessels, is considered as the characteristic of vascular aging. Calcifications at different vessel layers have different implications. Intimal calcification is closely related to atherosclerosis and affects plaque stability, while medial calcification can cause arterial stiffening and reduce compliance. Accumulating evidence suggested that arterial calcifications, including calcifications in the intracranial artery, coronary artery, and carotid artery, are associated with the risk, prognosis, and treatment response of stroke. VC can not only serve as a marker of atherosclerosis, but cause cerebral hemodynamic impairment. In addition, calcifications in large arteries are associated with cerebral small vessel disease. In this review, we summarize the findings of recently published studies focusing on the relationship between large artery calcification and the risk, prognosis, treatment response, and prevention of stroke and also discuss possible mechanisms behind those associations. |
| first_indexed | 2024-12-12T21:19:27Z |
| format | Article |
| id | doaj.art-84a199fa02e84beba45577122c77f70a |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T21:19:27Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-84a199fa02e84beba45577122c77f70a2022-12-22T00:11:39ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-05-011610.3389/fncel.2022.845215845215Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and PreventionXiang Wang0Xiang Wang1Xinghang Chen2Xinghang Chen3Zhuohui Chen4Zhuohui Chen5Mengqi Zhang6Mengqi Zhang7Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaStroke is a leading cause of death worldwide. Vascular calcification (VC), defined as deposition of calcium-phosphate complexes in the vessels, is considered as the characteristic of vascular aging. Calcifications at different vessel layers have different implications. Intimal calcification is closely related to atherosclerosis and affects plaque stability, while medial calcification can cause arterial stiffening and reduce compliance. Accumulating evidence suggested that arterial calcifications, including calcifications in the intracranial artery, coronary artery, and carotid artery, are associated with the risk, prognosis, and treatment response of stroke. VC can not only serve as a marker of atherosclerosis, but cause cerebral hemodynamic impairment. In addition, calcifications in large arteries are associated with cerebral small vessel disease. In this review, we summarize the findings of recently published studies focusing on the relationship between large artery calcification and the risk, prognosis, treatment response, and prevention of stroke and also discuss possible mechanisms behind those associations.https://www.frontiersin.org/articles/10.3389/fncel.2022.845215/fullarterial calcificationstrokecomputed tomographyradiographycalcification scoring method |
| spellingShingle | Xiang Wang Xiang Wang Xinghang Chen Xinghang Chen Zhuohui Chen Zhuohui Chen Mengqi Zhang Mengqi Zhang Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention Frontiers in Cellular Neuroscience arterial calcification stroke computed tomography radiography calcification scoring method |
| title | Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention |
| title_full | Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention |
| title_fullStr | Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention |
| title_full_unstemmed | Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention |
| title_short | Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention |
| title_sort | arterial calcification and its association with stroke implication of risk prognosis treatment response and prevention |
| topic | arterial calcification stroke computed tomography radiography calcification scoring method |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.845215/full |
| work_keys_str_mv | AT xiangwang arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT xiangwang arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT xinghangchen arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT xinghangchen arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT zhuohuichen arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT zhuohuichen arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT mengqizhang arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention AT mengqizhang arterialcalcificationanditsassociationwithstrokeimplicationofriskprognosistreatmentresponseandprevention |