α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes

α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes

Suppression of α/β-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG) hydrolase, promotes glucose-stimulated insulin secretion by pancreatic β cells. We report here that high-fat-diet-fed ABHD6-KO mice show modestly reduced food intake, decreased body weight gain and glycemia, improved glucose tol...

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Bibliographic Details
Main Authors: Shangang Zhao, Yves Mugabo, Gwynne Ballentine, Camille Attane, Jose Iglesias, Pegah Poursharifi, Dongwei Zhang, Thuy Anne Nguyen, Heidi Erb, Raphael Prentki, Marie-Line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju, Marc Prentki
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471630211X

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http://www.sciencedirect.com/science/article/pii/S221112471630211X

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