A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy
PurposeIn this study, we aim to further evaluate the accuracy of ultrasound tracking for intra-fraction pancreatic tumor motion during radiotherapy by a phantom-based study.MethodsTwelve patients with pancreatic cancer who were treated with stereotactic body radiation therapy were enrolled in this s...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.996537/full |
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| author | Tianlong Ji Tianlong Ji Ziwei Feng Ziwei Feng Edward Sun Sook Kien Ng Lin Su Yin Zhang Dong Han Sarah Han-Oh Iulian Iordachita Junghoon Lee Peter Kazanzides Muyinatu A. Lediju Bell John Wong Kai Ding |
| author_facet | Tianlong Ji Tianlong Ji Ziwei Feng Ziwei Feng Edward Sun Sook Kien Ng Lin Su Yin Zhang Dong Han Sarah Han-Oh Iulian Iordachita Junghoon Lee Peter Kazanzides Muyinatu A. Lediju Bell John Wong Kai Ding |
| author_sort | Tianlong Ji |
| collection | DOAJ |
| description | PurposeIn this study, we aim to further evaluate the accuracy of ultrasound tracking for intra-fraction pancreatic tumor motion during radiotherapy by a phantom-based study.MethodsTwelve patients with pancreatic cancer who were treated with stereotactic body radiation therapy were enrolled in this study. The displacement points of the respiratory cycle were acquired from 4DCT and transferred to a motion platform to mimic realistic breathing movements in our phantom study. An ultrasound abdominal phantom was placed and fixed in the motion platform. The ground truth of phantom movement was recorded by tracking an optical tracker attached to this phantom. One tumor inside the phantom was the tracking target. In the evaluation of the results, the monitoring results from the ultrasound system were compared with the phantom motion results from the infrared camera. Differences between infrared monitoring motion and ultrasound tracking motion were analyzed by calculating the root-mean-square error.ResultsThe 82.2% ultrasound tracking motion was within a 0.5 mm difference value between ultrasound tracking displacement and infrared monitoring motion. 0.7% ultrasound tracking failed to track accurately (a difference value > 2.5 mm). These differences between ultrasound tracking motion and infrared monitored motion do not correlate with respiratory displacements, respiratory velocity, or respiratory acceleration by linear regression analysis.ConclusionsThe highly accurate monitoring results of this phantom study prove that the ultrasound tracking system may be a potential method for real-time monitoring targets, allowing more accurate delivery of radiation doses. |
| first_indexed | 2024-04-12T03:05:00Z |
| format | Article |
| id | doaj.art-84a220d6c066436c977ccfc0843e13dd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T03:05:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-84a220d6c066436c977ccfc0843e13dd2022-12-22T03:50:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.996537996537A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapyTianlong Ji0Tianlong Ji1Ziwei Feng2Ziwei Feng3Edward Sun4Sook Kien Ng5Lin Su6Yin Zhang7Dong Han8Sarah Han-Oh9Iulian Iordachita10Junghoon Lee11Peter Kazanzides12Muyinatu A. Lediju Bell13John Wong14Kai Ding15Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesPurposeIn this study, we aim to further evaluate the accuracy of ultrasound tracking for intra-fraction pancreatic tumor motion during radiotherapy by a phantom-based study.MethodsTwelve patients with pancreatic cancer who were treated with stereotactic body radiation therapy were enrolled in this study. The displacement points of the respiratory cycle were acquired from 4DCT and transferred to a motion platform to mimic realistic breathing movements in our phantom study. An ultrasound abdominal phantom was placed and fixed in the motion platform. The ground truth of phantom movement was recorded by tracking an optical tracker attached to this phantom. One tumor inside the phantom was the tracking target. In the evaluation of the results, the monitoring results from the ultrasound system were compared with the phantom motion results from the infrared camera. Differences between infrared monitoring motion and ultrasound tracking motion were analyzed by calculating the root-mean-square error.ResultsThe 82.2% ultrasound tracking motion was within a 0.5 mm difference value between ultrasound tracking displacement and infrared monitoring motion. 0.7% ultrasound tracking failed to track accurately (a difference value > 2.5 mm). These differences between ultrasound tracking motion and infrared monitored motion do not correlate with respiratory displacements, respiratory velocity, or respiratory acceleration by linear regression analysis.ConclusionsThe highly accurate monitoring results of this phantom study prove that the ultrasound tracking system may be a potential method for real-time monitoring targets, allowing more accurate delivery of radiation doses.https://www.frontiersin.org/articles/10.3389/fonc.2022.996537/fullultrasound image trackingradiation therapyrespiratory motionultrasound imageabdominal |
| spellingShingle | Tianlong Ji Tianlong Ji Ziwei Feng Ziwei Feng Edward Sun Sook Kien Ng Lin Su Yin Zhang Dong Han Sarah Han-Oh Iulian Iordachita Junghoon Lee Peter Kazanzides Muyinatu A. Lediju Bell John Wong Kai Ding A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy Frontiers in Oncology ultrasound image tracking radiation therapy respiratory motion ultrasound image abdominal |
| title | A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| title_full | A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| title_fullStr | A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| title_full_unstemmed | A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| title_short | A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| title_sort | phantom based analysis for tracking intra fraction pancreatic tumor motion by ultrasound imaging during radiation therapy |
| topic | ultrasound image tracking radiation therapy respiratory motion ultrasound image abdominal |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.996537/full |
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