PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans.
C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidy...
| 主要な著者: | , , , , , |
|---|---|
| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Public Library of Science (PLoS)
2013-01-01
|
| シリーズ: | PLoS Genetics |
| オンライン･アクセス: | http://europepmc.org/articles/PMC3772066?pdf=render |
| _version_ | 1828240969007366144 |
|---|---|
| author | Emma Svensk Marcus Ståhlman Carl-Henrik Andersson Maja Johansson Jan Borén Marc Pilon |
| author_facet | Emma Svensk Marcus Ståhlman Carl-Henrik Andersson Maja Johansson Jan Borén Marc Pilon |
| author_sort | Emma Svensk |
| collection | DOAJ |
| description | C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant. |
| first_indexed | 2024-04-12T21:50:49Z |
| format | Article |
| id | doaj.art-84a40d049fe84d9986ee7066f1567ba2 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-12T21:50:49Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-84a40d049fe84d9986ee7066f1567ba22022-12-22T03:15:30ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042013-01-0199e100380110.1371/journal.pgen.1003801PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans.Emma SvenskMarcus StåhlmanCarl-Henrik AnderssonMaja JohanssonJan BorénMarc PilonC. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant.http://europepmc.org/articles/PMC3772066?pdf=render |
| spellingShingle | Emma Svensk Marcus Ståhlman Carl-Henrik Andersson Maja Johansson Jan Borén Marc Pilon PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genetics |
| title | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
| title_full | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
| title_fullStr | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
| title_full_unstemmed | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
| title_short | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
| title_sort | paqr 2 regulates fatty acid desaturation during cold adaptation in c elegans |
| url | http://europepmc.org/articles/PMC3772066?pdf=render |
| work_keys_str_mv | AT emmasvensk paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans AT marcusstahlman paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans AT carlhenrikandersson paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans AT majajohansson paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans AT janboren paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans AT marcpilon paqr2regulatesfattyaciddesaturationduringcoldadaptationincelegans |