Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics
Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemnes...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00451/full |
| _version_ | 1819262535777386496 |
|---|---|
| author | Sisi Cao Yaoyao Han Yaoyao Han Qiaofeng Li Qiaofeng Li Yanjiang Chen Dan Zhu Zhiheng Su Hongwei Guo Hongwei Guo |
| author_facet | Sisi Cao Yaoyao Han Yaoyao Han Qiaofeng Li Qiaofeng Li Yanjiang Chen Dan Zhu Zhiheng Su Hongwei Guo Hongwei Guo |
| author_sort | Sisi Cao |
| collection | DOAJ |
| description | Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of “multiple ingredients-multiple targets-multiple pathways” anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. The top ingredients, top targets, and top pathways of each anticancer function were identified using network pharmacology approach. Further intersecting analyses showed that Epigallocatechin gallate (EGCG), Gallic acid, Kaempferol, Luteolin, and Betulinic acid were the top ingredients which might be the key ingredients exerting anticancer function of Litchi, while BAX, BCL2, CASP3, and AKT1 were the top targets which might be the main targets underling the anticancer mechanisms of these top ingredients. These results provided references for further understanding and exploration of Litchi as therapeutics in cancer as well as the application of “Component Formula” based on Litchi’s effective ingredients. |
| first_indexed | 2024-12-23T19:59:15Z |
| format | Article |
| id | doaj.art-84a4f25eb6284c4ca190a262f5080080 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T19:59:15Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-84a4f25eb6284c4ca190a262f50800802022-12-21T17:33:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-04-011110.3389/fphar.2020.00451500835Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer TherapeuticsSisi Cao0Yaoyao Han1Yaoyao Han2Qiaofeng Li3Qiaofeng Li4Yanjiang Chen5Dan Zhu6Zhiheng Su7Hongwei Guo8Hongwei Guo9College of Pharmacy, Guangxi Medical University, Nanning, ChinaCollege of Pharmacy, Guangxi Medical University, Nanning, ChinaKey Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, Nanning, ChinaKey Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, Nanning, ChinaSchool of Preclinical Medicine, Guangxi Medical University, Nanning, ChinaDepartment of Surgery, University of Melbourne, Parkville, VIC, AustraliaCollege of Pharmacy, Guangxi Medical University, Nanning, ChinaCollege of Pharmacy, Guangxi Medical University, Nanning, ChinaCollege of Pharmacy, Guangxi Medical University, Nanning, ChinaKey Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, Nanning, ChinaConsiderable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of “multiple ingredients-multiple targets-multiple pathways” anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. The top ingredients, top targets, and top pathways of each anticancer function were identified using network pharmacology approach. Further intersecting analyses showed that Epigallocatechin gallate (EGCG), Gallic acid, Kaempferol, Luteolin, and Betulinic acid were the top ingredients which might be the key ingredients exerting anticancer function of Litchi, while BAX, BCL2, CASP3, and AKT1 were the top targets which might be the main targets underling the anticancer mechanisms of these top ingredients. These results provided references for further understanding and exploration of Litchi as therapeutics in cancer as well as the application of “Component Formula” based on Litchi’s effective ingredients.https://www.frontiersin.org/article/10.3389/fphar.2020.00451/fulllitchicancermulti-ingredientsmulti-targetsnetwork pharmacology |
| spellingShingle | Sisi Cao Yaoyao Han Yaoyao Han Qiaofeng Li Qiaofeng Li Yanjiang Chen Dan Zhu Zhiheng Su Hongwei Guo Hongwei Guo Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics Frontiers in Pharmacology litchi cancer multi-ingredients multi-targets network pharmacology |
| title | Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics |
| title_full | Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics |
| title_fullStr | Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics |
| title_full_unstemmed | Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics |
| title_short | Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics |
| title_sort | mapping pharmacological network of multi targeting litchi ingredients in cancer therapeutics |
| topic | litchi cancer multi-ingredients multi-targets network pharmacology |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00451/full |
| work_keys_str_mv | AT sisicao mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT yaoyaohan mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT yaoyaohan mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT qiaofengli mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT qiaofengli mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT yanjiangchen mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT danzhu mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT zhihengsu mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT hongweiguo mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics AT hongweiguo mappingpharmacologicalnetworkofmultitargetinglitchiingredientsincancertherapeutics |