Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
Liver failure is a common clinical syndrome of severe liver diseases, which belongs to one of the critical medical conditions. Immune response plays a leading role in the pathogenesis of liver failure. Lactic acid as a target for the treatment and prediction of liver failure has not attracted enough...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-09-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0636 |
| _version_ | 1797682403757522944 |
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| author | Lin Yong Yan Gengjie Wang Minggang Zhang Kan Shu Faming Liu Meiyan Long Fuli Mao Dewen |
| author_facet | Lin Yong Yan Gengjie Wang Minggang Zhang Kan Shu Faming Liu Meiyan Long Fuli Mao Dewen |
| author_sort | Lin Yong |
| collection | DOAJ |
| description | Liver failure is a common clinical syndrome of severe liver diseases, which belongs to one of the critical medical conditions. Immune response plays a leading role in the pathogenesis of liver failure. Lactic acid as a target for the treatment and prediction of liver failure has not attracted enough attention. Since the emergence of the concept of “histone lactation,” lactic acid has shown great promise in immune response and escape. Therefore, targeted lactic acid may be a reliable agent to solve immune and energy metabolism disorders in liver failure. Based on the relationship between lactic acid and immune response, the cross-talk between lactic acid metabolism, its compounds, and immune regulation and its significance in the diagnosis and treatment of liver failure were expounded in this article to provide new ideas for understanding and treating liver failure. |
| first_indexed | 2024-03-11T23:59:16Z |
| format | Article |
| id | doaj.art-84a6d0f4a7974bdfb5f2c8c47889f656 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-03-11T23:59:16Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-84a6d0f4a7974bdfb5f2c8c47889f6562023-09-18T06:31:22ZengDe GruyterOpen Life Sciences2391-54122023-09-01181202310.1515/biol-2022-0636Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failureLin Yong0Yan Gengjie1Wang Minggang2Zhang Kan3Shu Faming4Liu Meiyan5Long Fuli6Mao Dewen7Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaGraduate School of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Hepatology at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Hepatology at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Hepatology at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaGraduate School of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Hepatology at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Hepatology at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, ChinaLiver failure is a common clinical syndrome of severe liver diseases, which belongs to one of the critical medical conditions. Immune response plays a leading role in the pathogenesis of liver failure. Lactic acid as a target for the treatment and prediction of liver failure has not attracted enough attention. Since the emergence of the concept of “histone lactation,” lactic acid has shown great promise in immune response and escape. Therefore, targeted lactic acid may be a reliable agent to solve immune and energy metabolism disorders in liver failure. Based on the relationship between lactic acid and immune response, the cross-talk between lactic acid metabolism, its compounds, and immune regulation and its significance in the diagnosis and treatment of liver failure were expounded in this article to provide new ideas for understanding and treating liver failure.https://doi.org/10.1515/biol-2022-0636liver failurelactic acidimmunoregulatory response |
| spellingShingle | Lin Yong Yan Gengjie Wang Minggang Zhang Kan Shu Faming Liu Meiyan Long Fuli Mao Dewen Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure Open Life Sciences liver failure lactic acid immunoregulatory response |
| title | Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| title_full | Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| title_fullStr | Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| title_full_unstemmed | Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| title_short | Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| title_sort | crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure |
| topic | liver failure lactic acid immunoregulatory response |
| url | https://doi.org/10.1515/biol-2022-0636 |
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