Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation

Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation

Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-inducing enzyme. hCFPs target cancer cells via an ant...

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Bibliographic Details
Main Authors: Anna Bochicchio, Sandra Jordaan, Valeria Losasso, Shivan Chetty, Rodrigo Casasnovas Perera, Emiliano Ippoliti, Stefan Barth, Paolo Carloni
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Biomedicines
Subjects:
immunotherapy
targeted human cytolytic fusion proteins
molecular dynamics
high performance computing
Angiogenin
Granzyme B
Online Access:http://www.mdpi.com/2227-9059/5/1/9

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