PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice

PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice

Objective: Peroxiredoxin 1 (PRDX1) is a peroxidase and guards against oxidative stress by scavenging intracellular peroxides, whereas it also has been shown to stimulate inflammatory response by functioning as a chaperone protein. The potential in vivo link between PRDX1's peroxidase activity a...

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Bibliographic Details
Main Authors: Zhonghao Bai, Wen Yin, Rui Liu, Minglei Tang, Xiaofeng Shi, Cheng Luo, Xiangyang Xie
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Molecular Metabolism
Subjects:
PRDX1
NASH
Inflammation
Cys52
NF-κB
STAT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001230

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