Impact of Chikungunya on health related quality of life Chennai, South India.
BACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Fu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3520806?pdf=render |
| _version_ | 1828860169460645888 |
|---|---|
| author | Vidya Ramachandran Muniyandi Malaisamy Manickam Ponnaiah Kanagasabai Kaliaperuaml Selvaraj Vadivoo Mohan Digambar Gupte |
| author_facet | Vidya Ramachandran Muniyandi Malaisamy Manickam Ponnaiah Kanagasabai Kaliaperuaml Selvaraj Vadivoo Mohan Digambar Gupte |
| author_sort | Vidya Ramachandran |
| collection | DOAJ |
| description | BACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Further, we determined factors associated with clinical recovery among C-CHIKV patients. METHODS: We followed-up 403 of 425 adult C-CHIKV cases identified during an outbreak. On the basis of a reassessment of their current clinical status through self-reporting, we categorized them as 'clinically recovered' (n = 308) or 'not recovered' (n = 95). In the absence of base-line information on HRQoL, we included a comparison group of healthy normal's recruited by frequency matching for age and sex from the neighbourhood (n = 308). We conducted a comparative cross-sectional study of these three groups and estimated HRQoL scores using SF-36 questionnaire. We tested the differences in the median scores by Kruksall Wallistest. We identified factors associated with 'recovery' as compared to not-recovery by calculating Adjusted Odds Ratio (AOR) and 95% Confidence Intervals through multiple regression analysis. RESULTS: As compared to 'normals', we observed a 20 and five-fold reductions in HRQoL scores for C-CHIKV patients 'not recovered' and 'recovered' respectively. Differences in HRQoL scores for all the domains were statistically significant between three groups (p<0·001). Younger age, male, absence of rashes, affliction of less than five types of joints and two weeks of joint swelling were significantly associated with recovery. HRQoL scores improved with time among those 'clinically recovered'. CONCLUSION: This study provides evidence for sharp reductions in quality of life not only during active C-CHIKV associated illness but also for several months after clinical recovery compared to healthy normals. This has implications for developing intervention programmes in countries with high risk of CHIKV outbreaks. |
| first_indexed | 2024-12-13T02:32:46Z |
| format | Article |
| id | doaj.art-84ac9add6ca3456bacd5d19e73ff6495 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:32:46Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-84ac9add6ca3456bacd5d19e73ff64952022-12-22T00:02:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5151910.1371/journal.pone.0051519Impact of Chikungunya on health related quality of life Chennai, South India.Vidya RamachandranMuniyandi MalaisamyManickam PonnaiahKanagasabai KaliaperuamlSelvaraj VadivooMohan Digambar GupteBACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Further, we determined factors associated with clinical recovery among C-CHIKV patients. METHODS: We followed-up 403 of 425 adult C-CHIKV cases identified during an outbreak. On the basis of a reassessment of their current clinical status through self-reporting, we categorized them as 'clinically recovered' (n = 308) or 'not recovered' (n = 95). In the absence of base-line information on HRQoL, we included a comparison group of healthy normal's recruited by frequency matching for age and sex from the neighbourhood (n = 308). We conducted a comparative cross-sectional study of these three groups and estimated HRQoL scores using SF-36 questionnaire. We tested the differences in the median scores by Kruksall Wallistest. We identified factors associated with 'recovery' as compared to not-recovery by calculating Adjusted Odds Ratio (AOR) and 95% Confidence Intervals through multiple regression analysis. RESULTS: As compared to 'normals', we observed a 20 and five-fold reductions in HRQoL scores for C-CHIKV patients 'not recovered' and 'recovered' respectively. Differences in HRQoL scores for all the domains were statistically significant between three groups (p<0·001). Younger age, male, absence of rashes, affliction of less than five types of joints and two weeks of joint swelling were significantly associated with recovery. HRQoL scores improved with time among those 'clinically recovered'. CONCLUSION: This study provides evidence for sharp reductions in quality of life not only during active C-CHIKV associated illness but also for several months after clinical recovery compared to healthy normals. This has implications for developing intervention programmes in countries with high risk of CHIKV outbreaks.http://europepmc.org/articles/PMC3520806?pdf=render |
| spellingShingle | Vidya Ramachandran Muniyandi Malaisamy Manickam Ponnaiah Kanagasabai Kaliaperuaml Selvaraj Vadivoo Mohan Digambar Gupte Impact of Chikungunya on health related quality of life Chennai, South India. PLoS ONE |
| title | Impact of Chikungunya on health related quality of life Chennai, South India. |
| title_full | Impact of Chikungunya on health related quality of life Chennai, South India. |
| title_fullStr | Impact of Chikungunya on health related quality of life Chennai, South India. |
| title_full_unstemmed | Impact of Chikungunya on health related quality of life Chennai, South India. |
| title_short | Impact of Chikungunya on health related quality of life Chennai, South India. |
| title_sort | impact of chikungunya on health related quality of life chennai south india |
| url | http://europepmc.org/articles/PMC3520806?pdf=render |
| work_keys_str_mv | AT vidyaramachandran impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia AT muniyandimalaisamy impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia AT manickamponnaiah impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia AT kanagasabaikaliaperuaml impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia AT selvarajvadivoo impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia AT mohandigambargupte impactofchikungunyaonhealthrelatedqualityoflifechennaisouthindia |