Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling
We investigated the effect of post-labeling delay (PLD) on the evaluation of brain tumor blood flow using arterial spin labeling (ASL) magnetic resonance (MR) imaging to assess the need for imaging with two PLDs. Retrospective analysis was conducted on 63 adult patients with brain tumors who underwe...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/9/1/36 |
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| author | Ryutaro Ukisu Yusuke Inoue Hirofumi Hata Yoshihito Tanaka Rie Iwasaki |
| author_facet | Ryutaro Ukisu Yusuke Inoue Hirofumi Hata Yoshihito Tanaka Rie Iwasaki |
| author_sort | Ryutaro Ukisu |
| collection | DOAJ |
| description | We investigated the effect of post-labeling delay (PLD) on the evaluation of brain tumor blood flow using arterial spin labeling (ASL) magnetic resonance (MR) imaging to assess the need for imaging with two PLDs. Retrospective analysis was conducted on 63 adult patients with brain tumors who underwent contrast-enhanced MR imaging including ASL imaging with PLDs of both 1525 and 2525 ms on a 1.5 T or 3 T MR unit. Blood flow was estimated in the tumors and normal-appearing brain parenchyma, and tumor blood flow was normalized by parenchymal flow. Estimates of tumor blood flow, parenchymal flow, and normalized tumor flow showed no statistically significant differences between PLDs of 1525 and 2525 ms. Close correlations between different PLDs were found, with the closest correlation for normalized tumor flow. These results were similarly observed for the 1.5 T and 3 T units. The blood flow estimates obtained using ASL MR imaging in patients with brain tumors were highly concordant between PLDs of 1525 and 2525 ms, irrespective of the magnetic field strength. It is indicated that imaging with a single, standard PLD is acceptable for ASL assessment of brain tumor perfusion and that additional imaging with a long PLD is not required. |
| first_indexed | 2024-03-11T08:03:57Z |
| format | Article |
| id | doaj.art-84adc2d296544b7ea819585d2e5f840b |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-11T08:03:57Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-84adc2d296544b7ea819585d2e5f840b2023-11-16T23:36:46ZengMDPI AGTomography2379-13812379-139X2023-02-019143944810.3390/tomography9010036Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin LabelingRyutaro Ukisu0Yusuke Inoue1Hirofumi Hata2Yoshihito Tanaka3Rie Iwasaki4Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara 252-0374, Kanagawa, JapanDepartment of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara 252-0374, Kanagawa, JapanDepartment of Radiology, Kitasato University Hospital, Sagamihara 252-0375, Kanagawa, JapanDepartment of Radiology, Kitasato University Hospital, Sagamihara 252-0375, Kanagawa, JapanDepartment of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara 252-0374, Kanagawa, JapanWe investigated the effect of post-labeling delay (PLD) on the evaluation of brain tumor blood flow using arterial spin labeling (ASL) magnetic resonance (MR) imaging to assess the need for imaging with two PLDs. Retrospective analysis was conducted on 63 adult patients with brain tumors who underwent contrast-enhanced MR imaging including ASL imaging with PLDs of both 1525 and 2525 ms on a 1.5 T or 3 T MR unit. Blood flow was estimated in the tumors and normal-appearing brain parenchyma, and tumor blood flow was normalized by parenchymal flow. Estimates of tumor blood flow, parenchymal flow, and normalized tumor flow showed no statistically significant differences between PLDs of 1525 and 2525 ms. Close correlations between different PLDs were found, with the closest correlation for normalized tumor flow. These results were similarly observed for the 1.5 T and 3 T units. The blood flow estimates obtained using ASL MR imaging in patients with brain tumors were highly concordant between PLDs of 1525 and 2525 ms, irrespective of the magnetic field strength. It is indicated that imaging with a single, standard PLD is acceptable for ASL assessment of brain tumor perfusion and that additional imaging with a long PLD is not required.https://www.mdpi.com/2379-139X/9/1/36magnetic resonance imagingarterial spin labelingblood flowbrain tumorpost-labeling delay |
| spellingShingle | Ryutaro Ukisu Yusuke Inoue Hirofumi Hata Yoshihito Tanaka Rie Iwasaki Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling Tomography magnetic resonance imaging arterial spin labeling blood flow brain tumor post-labeling delay |
| title | Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling |
| title_full | Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling |
| title_fullStr | Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling |
| title_full_unstemmed | Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling |
| title_short | Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling |
| title_sort | effects of post labeling delay on magnetic resonance evaluation of brain tumor blood flow using arterial spin labeling |
| topic | magnetic resonance imaging arterial spin labeling blood flow brain tumor post-labeling delay |
| url | https://www.mdpi.com/2379-139X/9/1/36 |
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