The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study
Background: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity and infection prophylaxis, as its deficiency is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/3/329 |
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| author | Mihaela Dediu Ioana Mihaiela Ciuca Liviu Laurentiu Pop Daniela Iacob |
| author_facet | Mihaela Dediu Ioana Mihaiela Ciuca Liviu Laurentiu Pop Daniela Iacob |
| author_sort | Mihaela Dediu |
| collection | DOAJ |
| description | Background: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity and infection prophylaxis, as its deficiency is associated with frequent infections. In CF patients, a deficit of liposoluble vitamins is common, despite daily supplementation. The aim of this study is to evaluate the relation between vitamin D status and lung function expressed by lung clearance index (LCI) in patients with CF. We also assessed the relation of factors such as nutritional status, genotype, and associated comorbidities such as Pseudomonas infection, cystic fibrosis-related diabetes (CFRD), and cystic fibrosis liver disease (CFLD) with vitamin D and LCI. Methods: A cross-sectional study was conducted at the National Cystic Fibrosis Center by analyzing patients with CF who presented in our center between November 2017 and November 2019. We enrolled in the study patients diagnosed with CF, who were followed up in our CF center and who were able to perform lung function tests. Patients in exacerbation were excluded. Results: A strong negative correlation was found between vitamin D and LCI (r = −0.69, <i>p</i> = 0.000). A lower vitamin D storage was found in patients with CFLD and CFRD. Higher LCI values were found among patients with chronic Pseudomonas infection, with BMI under the 25th percentile, or with associated CFLD. Conclusion: In CF patients, vitamin D plays an important role, and its deficit correlates with an impaired LCI. Vitamin D deficit is a risk factor in patients with associated comorbidities such as CFLD and CFRD. Chronic infection with Pseudomonas, the presence of impaired nutritional status, and CFLD are associated with a prolonged LCI. |
| first_indexed | 2024-03-09T20:00:07Z |
| format | Article |
| id | doaj.art-84b0dde2778a4040a4af1a21cd35b9a1 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:00:07Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-84b0dde2778a4040a4af1a21cd35b9a12023-11-24T00:46:35ZengMDPI AGChildren2227-90672022-03-019332910.3390/children9030329The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot StudyMihaela Dediu0Ioana Mihaiela Ciuca1Liviu Laurentiu Pop2Daniela Iacob3Paediatric Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, RomaniaPaediatric Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, RomaniaPaediatric Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, RomaniaDepartment of Neonatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, RomaniaBackground: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity and infection prophylaxis, as its deficiency is associated with frequent infections. In CF patients, a deficit of liposoluble vitamins is common, despite daily supplementation. The aim of this study is to evaluate the relation between vitamin D status and lung function expressed by lung clearance index (LCI) in patients with CF. We also assessed the relation of factors such as nutritional status, genotype, and associated comorbidities such as Pseudomonas infection, cystic fibrosis-related diabetes (CFRD), and cystic fibrosis liver disease (CFLD) with vitamin D and LCI. Methods: A cross-sectional study was conducted at the National Cystic Fibrosis Center by analyzing patients with CF who presented in our center between November 2017 and November 2019. We enrolled in the study patients diagnosed with CF, who were followed up in our CF center and who were able to perform lung function tests. Patients in exacerbation were excluded. Results: A strong negative correlation was found between vitamin D and LCI (r = −0.69, <i>p</i> = 0.000). A lower vitamin D storage was found in patients with CFLD and CFRD. Higher LCI values were found among patients with chronic Pseudomonas infection, with BMI under the 25th percentile, or with associated CFLD. Conclusion: In CF patients, vitamin D plays an important role, and its deficit correlates with an impaired LCI. Vitamin D deficit is a risk factor in patients with associated comorbidities such as CFLD and CFRD. Chronic infection with Pseudomonas, the presence of impaired nutritional status, and CFLD are associated with a prolonged LCI.https://www.mdpi.com/2227-9067/9/3/329vitamin Dlung clearance indexlung functioncystic fibrosispediatric |
| spellingShingle | Mihaela Dediu Ioana Mihaiela Ciuca Liviu Laurentiu Pop Daniela Iacob The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study Children vitamin D lung clearance index lung function cystic fibrosis pediatric |
| title | The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study |
| title_full | The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study |
| title_fullStr | The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study |
| title_full_unstemmed | The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study |
| title_short | The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study |
| title_sort | relation between vitamin d level and lung clearance index in cystic fibrosis a pilot study |
| topic | vitamin D lung clearance index lung function cystic fibrosis pediatric |
| url | https://www.mdpi.com/2227-9067/9/3/329 |
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