Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience.
Liver cancer is the sixth most common cancer worldwide in terms of the number of cases (626,000 or 5.7% of new cancer cases) but due to the very poor prognosis, the number of deaths is nearly similar (598,000). The survival rate is 3% to 5% in cancer registries for the United States and developing...
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| Format: | Article |
| Language: | English |
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Albanian Society for Trauma and Emergency Surgery
2022-07-01
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| Series: | Albanian Journal of Trauma and Emergency Surgery |
| Subjects: | |
| Online Access: | http://journal.astes.org.al/index.php/AJTES/article/view/291 |
| _version_ | 1811296265123659776 |
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| author | Ilirian Laçi Alketa Spahiu |
| author_facet | Ilirian Laçi Alketa Spahiu |
| author_sort | Ilirian Laçi |
| collection | DOAJ |
| description |
Liver cancer is the sixth most common cancer worldwide in terms of the number of cases (626,000 or 5.7% of new cancer cases) but due to the very poor prognosis, the number of deaths is nearly similar (598,000). The survival rate is 3% to 5% in cancer registries for the United States and developing countries. The modality of treatment in hepatocellular carcinoma (HCC) patients depends on the stage of the disease. The Barcelona Clinic Liver Cancer Classification (BCLC) is the favorite staging system. There are many patients who initially present with the intermediate-stage disease, and in this setting transarterial chemoembolization (TACE) is the treatment of choice.
The purpose of this article is to highlight and discuss the role of chemoembolization in the treatment of hepatocellular carcinoma, including the results of recent large studies, and the concept of combined therapies, illustrating our case.
The differences in individual factors that are not captured by the BCLC framework, such as the tumor growth pattern, degree of hypervascularity, and vascular supply, complicate the further evaluation of these patients. Because of these differences, not all patients benefit equally from TACE. Several tools have been devised to aid the decision-making process which have shown promising initial results but have failed external evaluation and have not been translated to the clinical aspects. Criteria for treatment decisions in daily clinical practice are needed in all stages of the disease.
Conclusion: TACE is a safe method for prolonging patients' survival with unresectable HCC. The correct treatment of HCC is concentrated in cancer centers, and cooperation between multiple specialists is necessary.
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| first_indexed | 2024-04-13T05:46:40Z |
| format | Article |
| id | doaj.art-84b16a8d6bb242fdbf85862db1bfcc09 |
| institution | Directory Open Access Journal |
| issn | 2521-8778 2616-4922 |
| language | English |
| last_indexed | 2024-04-13T05:46:40Z |
| publishDate | 2022-07-01 |
| publisher | Albanian Society for Trauma and Emergency Surgery |
| record_format | Article |
| series | Albanian Journal of Trauma and Emergency Surgery |
| spelling | doaj.art-84b16a8d6bb242fdbf85862db1bfcc092022-12-22T02:59:56ZengAlbanian Society for Trauma and Emergency SurgeryAlbanian Journal of Trauma and Emergency Surgery2521-87782616-49222022-07-016210.32391/ajtes.v6i2.291Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience.Ilirian Laçi0Alketa Spahiu1Departament of Radiology and Nuclear Medicine, University Hospital Center “Mother Theresa” Tirana, AlbaniaNefrologist, Polyclinic of Specialties No. 3, Tirana, Albania Liver cancer is the sixth most common cancer worldwide in terms of the number of cases (626,000 or 5.7% of new cancer cases) but due to the very poor prognosis, the number of deaths is nearly similar (598,000). The survival rate is 3% to 5% in cancer registries for the United States and developing countries. The modality of treatment in hepatocellular carcinoma (HCC) patients depends on the stage of the disease. The Barcelona Clinic Liver Cancer Classification (BCLC) is the favorite staging system. There are many patients who initially present with the intermediate-stage disease, and in this setting transarterial chemoembolization (TACE) is the treatment of choice. The purpose of this article is to highlight and discuss the role of chemoembolization in the treatment of hepatocellular carcinoma, including the results of recent large studies, and the concept of combined therapies, illustrating our case. The differences in individual factors that are not captured by the BCLC framework, such as the tumor growth pattern, degree of hypervascularity, and vascular supply, complicate the further evaluation of these patients. Because of these differences, not all patients benefit equally from TACE. Several tools have been devised to aid the decision-making process which have shown promising initial results but have failed external evaluation and have not been translated to the clinical aspects. Criteria for treatment decisions in daily clinical practice are needed in all stages of the disease. Conclusion: TACE is a safe method for prolonging patients' survival with unresectable HCC. The correct treatment of HCC is concentrated in cancer centers, and cooperation between multiple specialists is necessary. http://journal.astes.org.al/index.php/AJTES/article/view/291hepatocellular carcinomachemoembolizationtranscatheter therapyTACE |
| spellingShingle | Ilirian Laçi Alketa Spahiu Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. Albanian Journal of Trauma and Emergency Surgery hepatocellular carcinoma chemoembolization transcatheter therapy TACE |
| title | Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. |
| title_full | Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. |
| title_fullStr | Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. |
| title_full_unstemmed | Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. |
| title_short | Transarterial Chemoembolization in Hepatocellular Carcinoma, Albanian Experience. |
| title_sort | transarterial chemoembolization in hepatocellular carcinoma albanian experience |
| topic | hepatocellular carcinoma chemoembolization transcatheter therapy TACE |
| url | http://journal.astes.org.al/index.php/AJTES/article/view/291 |
| work_keys_str_mv | AT ilirianlaci transarterialchemoembolizationinhepatocellularcarcinomaalbanianexperience AT alketaspahiu transarterialchemoembolizationinhepatocellularcarcinomaalbanianexperience |