Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Abstract Background Destruction of blood–brain barrier (BBB) ​​is one of the main mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Frizzled-7 is a key protein expressed on the surface of endothelial cells that controls vascular permeability through the Wnt-canonical pat...

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Bibliographic Details
Main Authors: Wei He, Qin Lu, Prativa Sherchan, Lei Huang, Xin Hu, John H. Zhang, Haibin Dai, Jiping Tang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Fluids and Barriers of the CNS
Subjects:
Intracerebral hemorrhage
Blood–brain barrier
Frizzled-7
Dvl
β-Catenin
WISP1
Online Access:https://doi.org/10.1186/s12987-021-00278-9

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