VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells

VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells

Abstract Variability of gene expression due to stochasticity of transcription or variation of extrinsic signals, termed biological noise, is a potential driving force of cellular differentiation. Utilizing single-cell RNA-sequencing, we develop VarID2 for the quantification of biological noise at si...

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Bibliographic Details
Main Authors: Reyna Edith Rosales-Alvarez, Jasmin Rettkowski, Josip Stefan Herman, Gabrijela Dumbović, Nina Cabezas-Wallscheid, Dominic Grün
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Genome Biology
Subjects:
Gene expression noise
Single-cell RNA sequencing
Stem cell differentiation
Cell sate variability
Ageing
Hematopoietic stem cells
Online Access:https://doi.org/10.1186/s13059-023-02974-1

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