Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study
Abstract Background Plasma D-dimer level, a marker of hypercoagulation, has been reported to be associated with survival in several types of cancers. The present study aimed to evaluate the prognostic significance of preoperative D-dimer levels in patients with surgically resected clinical stage I n...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13019-017-0676-3 |
| _version_ | 1828167683525312512 |
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| author | Kaoru Kaseda Keisuke Asakura Akio Kazama Yukihiko Ozawa |
| author_facet | Kaoru Kaseda Keisuke Asakura Akio Kazama Yukihiko Ozawa |
| author_sort | Kaoru Kaseda |
| collection | DOAJ |
| description | Abstract Background Plasma D-dimer level, a marker of hypercoagulation, has been reported to be associated with survival in several types of cancers. The present study aimed to evaluate the prognostic significance of preoperative D-dimer levels in patients with surgically resected clinical stage I non-small cell lung cancer (NSCLC). Methods Participants comprised 237 patients with surgically resected clinical stage I NSCLC. In addition to factors such as age, sex, and smoking status, the association between preoperative D-dimer level and survival was explored. Results Patients were divided into two groups according to D-dimer level: Group A, ≤ 1.0 μg/ml (n = 170); and Group B, > 1.0 μg/ml (n = 67). The 5-year recurrence-free survival rate was 81.6% for Group A and 66.6% for Group B (p < 0.001). The 5-year overall survival rate was 93.6% for Group A and 84.7% for Group B (p = 0.002). Multivariate survival analysis identified D-dimer level as an independent prognostic factor, along with age, maximum standardized uptake value of the primary tumor, and pathological stage. Conclusions Preoperative D-dimer level is an independent prognostic factor in patients with surgically resected clinical stage I NSCLC. |
| first_indexed | 2024-04-12T02:21:18Z |
| format | Article |
| id | doaj.art-84b7647572744e1d9be1df2ea34e0f85 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-12T02:21:18Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-84b7647572744e1d9be1df2ea34e0f852022-12-22T03:52:07ZengBMCJournal of Cardiothoracic Surgery1749-80902017-11-011211810.1186/s13019-017-0676-3Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort studyKaoru Kaseda0Keisuke Asakura1Akio Kazama2Yukihiko Ozawa3Department of Thoracic Surgery, Sagamihara Kyodo HospitalDepartment of Thoracic Surgery, Sagamihara Kyodo HospitalDepartment of Pathology, Sagamihara Kyodo HospitalYuai ClinicAbstract Background Plasma D-dimer level, a marker of hypercoagulation, has been reported to be associated with survival in several types of cancers. The present study aimed to evaluate the prognostic significance of preoperative D-dimer levels in patients with surgically resected clinical stage I non-small cell lung cancer (NSCLC). Methods Participants comprised 237 patients with surgically resected clinical stage I NSCLC. In addition to factors such as age, sex, and smoking status, the association between preoperative D-dimer level and survival was explored. Results Patients were divided into two groups according to D-dimer level: Group A, ≤ 1.0 μg/ml (n = 170); and Group B, > 1.0 μg/ml (n = 67). The 5-year recurrence-free survival rate was 81.6% for Group A and 66.6% for Group B (p < 0.001). The 5-year overall survival rate was 93.6% for Group A and 84.7% for Group B (p = 0.002). Multivariate survival analysis identified D-dimer level as an independent prognostic factor, along with age, maximum standardized uptake value of the primary tumor, and pathological stage. Conclusions Preoperative D-dimer level is an independent prognostic factor in patients with surgically resected clinical stage I NSCLC.http://link.springer.com/article/10.1186/s13019-017-0676-3D-dimerNon-small cell lung cancerPrognosis |
| spellingShingle | Kaoru Kaseda Keisuke Asakura Akio Kazama Yukihiko Ozawa Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study Journal of Cardiothoracic Surgery D-dimer Non-small cell lung cancer Prognosis |
| title | Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study |
| title_full | Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study |
| title_fullStr | Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study |
| title_full_unstemmed | Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study |
| title_short | Prognostic significance of preoperative plasma D-dimer level in patients with surgically resected clinical stage I non-small cell lung cancer: a retrospective cohort study |
| title_sort | prognostic significance of preoperative plasma d dimer level in patients with surgically resected clinical stage i non small cell lung cancer a retrospective cohort study |
| topic | D-dimer Non-small cell lung cancer Prognosis |
| url | http://link.springer.com/article/10.1186/s13019-017-0676-3 |
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