Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
Background: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing...
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2023-01-01
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Series: | Revista de Investigación Clínica |
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author | Silvia Cid-Juárez Norma A. Téllez-Navarrete Anaid Bautista-Bernal Pablo León-Gómez Isabel Salas-Escamilla Laura Gochicoa-Rangel Rogelio Pérez-Padilla |
author_facet | Silvia Cid-Juárez Norma A. Téllez-Navarrete Anaid Bautista-Bernal Pablo León-Gómez Isabel Salas-Escamilla Laura Gochicoa-Rangel Rogelio Pérez-Padilla |
author_sort | Silvia Cid-Juárez |
collection | DOAJ |
description | Background: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods: We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results: Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion: Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level.
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language | English |
last_indexed | 2024-04-10T06:36:24Z |
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spelling | doaj.art-84b7b68b888a44b48a3ccbbf20d74ba32023-02-28T20:30:35ZengPermanyerRevista de Investigación Clínica0034-83762564-88962023-01-0175110.24875/RIC.22000281Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass IndexSilvia Cid-Juárez0Norma A. Téllez-Navarrete1Anaid Bautista-Bernal2Pablo León-Gómez3Isabel Salas-Escamilla4Laura Gochicoa-Rangel5Rogelio Pérez-Padilla6National Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoBackground: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods: We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results: Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion: Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=451Oxygenation. Hyperventilation. Arterial blood gases. Altitude. |
spellingShingle | Silvia Cid-Juárez Norma A. Téllez-Navarrete Anaid Bautista-Bernal Pablo León-Gómez Isabel Salas-Escamilla Laura Gochicoa-Rangel Rogelio Pérez-Padilla Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index Revista de Investigación Clínica Oxygenation. Hyperventilation. Arterial blood gases. Altitude. |
title | Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index |
title_full | Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index |
title_fullStr | Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index |
title_full_unstemmed | Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index |
title_short | Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index |
title_sort | arterial blood gases in normal subjects at 2240 meters above sea level impact of age gender and body mass index |
topic | Oxygenation. Hyperventilation. Arterial blood gases. Altitude. |
url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=451 |
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