Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index

Background: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing...

Full description

Bibliographic Details
Main Authors: Silvia Cid-Juárez, Norma A. Téllez-Navarrete, Anaid Bautista-Bernal, Pablo León-Gómez, Isabel Salas-Escamilla, Laura Gochicoa-Rangel, Rogelio Pérez-Padilla
Format: Article
Language:English
Published: Permanyer 2023-01-01
Series:Revista de Investigación Clínica
Subjects:
Online Access:https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=451
_version_ 1811162880115998720
author Silvia Cid-Juárez
Norma A. Téllez-Navarrete
Anaid Bautista-Bernal
Pablo León-Gómez
Isabel Salas-Escamilla
Laura Gochicoa-Rangel
Rogelio Pérez-Padilla
author_facet Silvia Cid-Juárez
Norma A. Téllez-Navarrete
Anaid Bautista-Bernal
Pablo León-Gómez
Isabel Salas-Escamilla
Laura Gochicoa-Rangel
Rogelio Pérez-Padilla
author_sort Silvia Cid-Juárez
collection DOAJ
description Background: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods: We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results: Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion: Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level.
first_indexed 2024-04-10T06:36:24Z
format Article
id doaj.art-84b7b68b888a44b48a3ccbbf20d74ba3
institution Directory Open Access Journal
issn 0034-8376
2564-8896
language English
last_indexed 2024-04-10T06:36:24Z
publishDate 2023-01-01
publisher Permanyer
record_format Article
series Revista de Investigación Clínica
spelling doaj.art-84b7b68b888a44b48a3ccbbf20d74ba32023-02-28T20:30:35ZengPermanyerRevista de Investigación Clínica0034-83762564-88962023-01-0175110.24875/RIC.22000281Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass IndexSilvia Cid-Juárez0Norma A. Téllez-Navarrete1Anaid Bautista-Bernal2Pablo León-Gómez3Isabel Salas-Escamilla4Laura Gochicoa-Rangel5Rogelio Pérez-Padilla6National Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoNational Institute of Respiratory Diseases (INER), Mexico City, MexicoBackground: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population’s adaptation. Objective: The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods: We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results: Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion: Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=451Oxygenation. Hyperventilation. Arterial blood gases. Altitude.
spellingShingle Silvia Cid-Juárez
Norma A. Téllez-Navarrete
Anaid Bautista-Bernal
Pablo León-Gómez
Isabel Salas-Escamilla
Laura Gochicoa-Rangel
Rogelio Pérez-Padilla
Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
Revista de Investigación Clínica
Oxygenation. Hyperventilation. Arterial blood gases. Altitude.
title Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
title_full Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
title_fullStr Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
title_full_unstemmed Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
title_short Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
title_sort arterial blood gases in normal subjects at 2240 meters above sea level impact of age gender and body mass index
topic Oxygenation. Hyperventilation. Arterial blood gases. Altitude.
url https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=451
work_keys_str_mv AT silviacidjuarez arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT normaatelleznavarrete arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT anaidbautistabernal arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT pabloleongomez arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT isabelsalasescamilla arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT lauragochicoarangel arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex
AT rogelioperezpadilla arterialbloodgasesinnormalsubjectsat2240metersabovesealevelimpactofagegenderandbodymassindex