Dendritic Cell Regulation by Cannabinoid-Based Drugs
Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and cancer, as well as neuroinflammatory and chron...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8247/3/8/2733/ |
| _version_ | 1811286937932136448 |
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| author | Mattias Svensson Puran Chen Oscar Hammarfjord |
| author_facet | Mattias Svensson Puran Chen Oscar Hammarfjord |
| author_sort | Mattias Svensson |
| collection | DOAJ |
| description | Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and cancer, as well as neuroinflammatory and chronic inflammatory diseases. Moreover, as we discuss here, additional studies also indicates that these drugs have immunosuppressive and anti-inflammatory properties including modulation of immune cell function. Thus, manipulation of the endocannabinoid system in vivo may provide novel therapeutic strategies against inflammatory disorders. At least two types of cannabinoid receptors, cannabinoid 1 and cannabinoid 2 receptors are expressed on immune cells such as dendritic cells (DC). Dendritic cells are recognized for their critical role in initiating and maintaining immune responses. Therefore, DC are potential targets for cannabinoid-mediated modulation. Here, we review the effects of cannabinoids on DC and provide some perspective concerning the therapeutic potential of cannabinoids for the treatment of human diseases involving aberrant inflammatory processes. |
| first_indexed | 2024-04-13T03:08:50Z |
| format | Article |
| id | doaj.art-84b7ba218f474e81870068e96f0c6630 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-13T03:08:50Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-84b7ba218f474e81870068e96f0c66302022-12-22T03:05:08ZengMDPI AGPharmaceuticals1424-82472010-08-01382733275010.3390/ph3082733Dendritic Cell Regulation by Cannabinoid-Based DrugsMattias SvenssonPuran ChenOscar HammarfjordCannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and cancer, as well as neuroinflammatory and chronic inflammatory diseases. Moreover, as we discuss here, additional studies also indicates that these drugs have immunosuppressive and anti-inflammatory properties including modulation of immune cell function. Thus, manipulation of the endocannabinoid system in vivo may provide novel therapeutic strategies against inflammatory disorders. At least two types of cannabinoid receptors, cannabinoid 1 and cannabinoid 2 receptors are expressed on immune cells such as dendritic cells (DC). Dendritic cells are recognized for their critical role in initiating and maintaining immune responses. Therefore, DC are potential targets for cannabinoid-mediated modulation. Here, we review the effects of cannabinoids on DC and provide some perspective concerning the therapeutic potential of cannabinoids for the treatment of human diseases involving aberrant inflammatory processes.http://www.mdpi.com/1424-8247/3/8/2733/Cannabinoidsdendritic cellsinflammationimmunomodulationKV-channels |
| spellingShingle | Mattias Svensson Puran Chen Oscar Hammarfjord Dendritic Cell Regulation by Cannabinoid-Based Drugs Pharmaceuticals Cannabinoids dendritic cells inflammation immunomodulation KV-channels |
| title | Dendritic Cell Regulation by Cannabinoid-Based Drugs |
| title_full | Dendritic Cell Regulation by Cannabinoid-Based Drugs |
| title_fullStr | Dendritic Cell Regulation by Cannabinoid-Based Drugs |
| title_full_unstemmed | Dendritic Cell Regulation by Cannabinoid-Based Drugs |
| title_short | Dendritic Cell Regulation by Cannabinoid-Based Drugs |
| title_sort | dendritic cell regulation by cannabinoid based drugs |
| topic | Cannabinoids dendritic cells inflammation immunomodulation KV-channels |
| url | http://www.mdpi.com/1424-8247/3/8/2733/ |
| work_keys_str_mv | AT mattiassvensson dendriticcellregulationbycannabinoidbaseddrugs AT puranchen dendriticcellregulationbycannabinoidbaseddrugs AT oscarhammarfjord dendriticcellregulationbycannabinoidbaseddrugs |