Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein

Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein

<p>Abstract</p> <p>Background</p> <p>Engineered proteins, with non-immunoglobulin scaffolds, have become an important alternative to antibodies in many biotechnical and therapeutic applications. When compared to antibodies, tailored proteins may provide advantageous pro...

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Bibliographic Details
Main Authors: Kulomaa Markku S, Hinterdorfer Peter, Ebner Andreas, Määttä Juha AE, Nordlund Henri R, Rangl Martina, Hiltunen Soili, Riihimäki Tiina A, Takkinen Kristiina, Hytönen Vesa P
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Biotechnology
Subjects:
protein engineering
avidin scaffold
phage display
steroid hormone
testosterone
Online Access:http://www.biomedcentral.com/1472-6750/11/64

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