| Summary: | Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-β is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-β levels in CSF and its correlation with CSF.
Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-β and thrombolysis in myocardial infarction frame count (TFC).
Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80+-1.2 vs. 2.21+-1.2 mg/dL, p=0.011), salusin-β [1205 (330–2092) vs. 162 (29–676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29+-9 vs. 19.7+-3.7, p<0.001), circumflex artery TFC (25+-10 vs. 15+-3.2, p<0.001), right coronary artery TFC (28+-7.1 vs. 13+-3.3, p<0.001), and mean TFC (28+-4.4 vs. 16+-3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized β+-SE=0.178+-0.08, p=0.036) and salusin-β levels (unstandardized β+-SE=0.006+-0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-β and mean TFC values (r=0.564; p<0.001).
Conclusion: There is an association between serum salusin-β levels and CSF.
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