Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds

Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds

Abstract Genetically engineered mice (GEM) are the gold standard for cancer modeling. However, strict recapitulation of stepwise carcinogenesis from a single tumor-initiating epithelial cell among genetically intact cells in adults is not feasible with the currently available techniques using GEM. I...

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Bibliographic Details
Main Authors: Shingo Kato, Kentaro Fushimi, Yuichiro Yabuki, Yoshiaki Maru, Sho Hasegawa, Tetsuya Matsuura, Daisuke Kurotaki, Akihiro Suzuki, Noritoshi Kobayashi, Masato Yoneda, Takuma Higurashi, Makiko Enaka, Tomohiko Tamura, Yoshitaka Hippo, Atsushi Nakajima
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00322-1

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