Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Models

Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Models

Non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in the liver, is the most common cause of liver diseases in Western countries. NAFLD is a major risk factor for developing hepatocellular carcinoma (HCC); however, in vitro evaluation of hepatic cancerogenesis fails due t...

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Bibliographic Details
Main Authors: Andrea Scheffschick, Jonas Babel, Sebastian Sperling, Julia Nerusch, Natalie Herzog, Daniel Seehofer, Georg Damm
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biology
Subjects:
upcyte hepatocytes
primary human hepatocytes
HepG2 cells
HCC
energy metabolism
Online Access:https://www.mdpi.com/2079-7737/11/8/1195

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