Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour

Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour

AbstractParoxetine is not suitable for oral administration due to its extensive first-pass metabolism, thus resulting in less bioavailability. This study aimed to prepare novel paroxetine-loaded solid lipid nanoparticles (SLNs) based sustained-release transdermal patches to overcome these problems b...

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Bibliographic Details
Main Authors: Fahad Pervaiz, Ayesha Saba, Haya Yasin, Manal Buabeid, Sobia Noreen, Abida Kalsoom Khan, Ghulam Murtaza
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Paroxetine
solid lipid nanoparticles
transdermal patch
ex vivo permeation
ethylcellulose
polyvinyl pyrrolidone
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2023.2179631

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