Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency
Purpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone levels and hypogonadal symptoms. Materials and Me...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society for Sexual Medicine and Andrology
2024-01-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1797383000455905280 |
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| author | Tae Yong Park Moon Young Choi Dong Soo Kim Jeong Kyun Yeo Mahadevan Rajasekaran Min Gu Park |
| author_facet | Tae Yong Park Moon Young Choi Dong Soo Kim Jeong Kyun Yeo Mahadevan Rajasekaran Min Gu Park |
| author_sort | Tae Yong Park |
| collection | DOAJ |
| description | Purpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after
testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone
levels and hypogonadal symptoms.
Materials and Methods: Seventy patients with TD were divided into control (group I, n=23) and experimental (group II, n=47)
groups. Patients in the experimental group were administered intramuscular testosterone enanthate (250 mg) for six months. The
aging males symptom scale (AMS) score, international prostate symptom score (IPSS), body mass index, waist circumference,
and serum laboratory values were measured at baseline and at the end of the study. Bioelectrical impedance analysis was used
to assess the patients’ body composition. Seven types of basic exercise tests were used to evaluate the patients’ physical fitness.
Results: After six months, there were no significant differences in group I, while group II had significantly improved IPSS and
AMS scores; increased hemoglobin, hematocrit, prostate-specific antigen, and testosterone levels and skeletal muscle mass;
and waist circumference, and body fat mass. All elements of the physical fitness test were significantly improved in group II,
with the exceptions of flexibility and endurance. Decreased waist circumference was correlated with changes in testosterone
levels in group II, and the IPSS, cardiorespiratory fitness, and agility were correlated with improved hypogonadal symptoms.
Conclusions: TT improved the hypogonadal and lower urinary tract symptoms in patients with TD and improved body composition,
physical fitness, and metabolic syndrome parameters. Increased testosterone and improved hypogonadal symptoms
were correlated with a decrease in waist circumference and an improvement in cardiorespiratory fitness and agility. As such,
when implementing TT, we should consider whether these areas may be improved, as this can help to predict the effect. |
| first_indexed | 2024-03-08T21:14:26Z |
| format | Article |
| id | doaj.art-84c57898c5fb4343ae41f7f6e6c5b424 |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-03-08T21:14:26Z |
| publishDate | 2024-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-84c57898c5fb4343ae41f7f6e6c5b4242023-12-22T02:45:01ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902024-01-0142117818710.5534/wjmh.220274Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone DeficiencyTae Yong Park0https://orcid.org/0000-0002-6692-6397Moon Young Choi1https://orcid.org/0000-0002-1381-1166Dong Soo Kim2https://orcid.org/0000-0002-5696-0671Jeong Kyun Yeo3https://orcid.org/0000-0001-5027-3451Mahadevan Rajasekaran4https://orcid.org/0000-0003-4188-1628Min Gu Park5https://orcid.org/0000-0001-5704-5320Department of Medicine, Graduate School, Korea University, SeoulSports Medical Center and Sports Medicine Research Institute, Inje University Seoul Paik HospitalDepartment of Urology, Kyung Hee University Medical Center, School of Medicine, Kyung Hee UniversityDepartment of Urology, Inje University Seoul Paik Hospital, Inje University College of Medicine, SeoulDepartment of Medicine, VA San Diego Health Care System, University of California, San Diego, CADepartment of Urology, Inje University Seoul Paik Hospital, Inje University College of Medicine, SeoulPurpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone levels and hypogonadal symptoms. Materials and Methods: Seventy patients with TD were divided into control (group I, n=23) and experimental (group II, n=47) groups. Patients in the experimental group were administered intramuscular testosterone enanthate (250 mg) for six months. The aging males symptom scale (AMS) score, international prostate symptom score (IPSS), body mass index, waist circumference, and serum laboratory values were measured at baseline and at the end of the study. Bioelectrical impedance analysis was used to assess the patients’ body composition. Seven types of basic exercise tests were used to evaluate the patients’ physical fitness. Results: After six months, there were no significant differences in group I, while group II had significantly improved IPSS and AMS scores; increased hemoglobin, hematocrit, prostate-specific antigen, and testosterone levels and skeletal muscle mass; and waist circumference, and body fat mass. All elements of the physical fitness test were significantly improved in group II, with the exceptions of flexibility and endurance. Decreased waist circumference was correlated with changes in testosterone levels in group II, and the IPSS, cardiorespiratory fitness, and agility were correlated with improved hypogonadal symptoms. Conclusions: TT improved the hypogonadal and lower urinary tract symptoms in patients with TD and improved body composition, physical fitness, and metabolic syndrome parameters. Increased testosterone and improved hypogonadal symptoms were correlated with a decrease in waist circumference and an improvement in cardiorespiratory fitness and agility. As such, when implementing TT, we should consider whether these areas may be improved, as this can help to predict the effect.body compositionhormone replacement therapyhypgonadismlower urinary tract symptomsphysical fitnesstestosterone |
| spellingShingle | Tae Yong Park Moon Young Choi Dong Soo Kim Jeong Kyun Yeo Mahadevan Rajasekaran Min Gu Park Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency The World Journal of Men's Health body composition hormone replacement therapy hypgonadism lower urinary tract symptoms physical fitness testosterone |
| title | Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency |
| title_full | Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency |
| title_fullStr | Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency |
| title_full_unstemmed | Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency |
| title_short | Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency |
| title_sort | correlation analysis between hypogonadal symptoms and changes in body composition and physical fitness after testosterone treatment in men with testosterone deficiency |
| topic | body composition hormone replacement therapy hypgonadism lower urinary tract symptoms physical fitness testosterone |
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