Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry
Background/Purpose: We investigated the diagnostic performance of the anal sphincter relaxation integral (ASRI) for infants with Hirschsprung's disease (HD). Methods: We performed water-perfused high-resolution anorectal manometry (HRAM) in 18 infants (9 with HD), and solid-state HRAM in anothe...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664623003273 |
| _version_ | 1827339745731018752 |
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| author | Jia-Feng Wu Yu-Cheng Lin Chia-Hsiang Yang Ping-Huei Tseng I-Jung Tsai Wen-Hsi Lin Wen-Ming Hsu |
| author_facet | Jia-Feng Wu Yu-Cheng Lin Chia-Hsiang Yang Ping-Huei Tseng I-Jung Tsai Wen-Hsi Lin Wen-Ming Hsu |
| author_sort | Jia-Feng Wu |
| collection | DOAJ |
| description | Background/Purpose: We investigated the diagnostic performance of the anal sphincter relaxation integral (ASRI) for infants with Hirschsprung's disease (HD). Methods: We performed water-perfused high-resolution anorectal manometry (HRAM) in 18 infants (9 with HD), and solid-state HRAM in another 18 infants (4 with HD). We calculated the ASRI during the rectoanal inhibitory reflex (RAIR) maneuver at pressure cutoffs of <10 mmHg (ASRI 10) and <15 mmHg (ASRI 15). We investigated the diagnostic performance of the ASRI for HD in infants undergoing water-perfused and solid-state HRAM. Results: HD infants who underwent either water-perfused or solid-state HRAM had significantly lower ASRI 10 and ASRI 15 values, compared with non-HD infants (P < 0.05 and P < 0.05, respectively). Using the water-perfused HRAM system, ASRI 10 and ASRI 15 values of <7 and <29 mmHg s.cm, respectively, exhibited good diagnostic performance for HD (88.89% and 88.89%, respectively). Receiver operating characteristic curve analysis indicated that ASRI 10 and ASRI 15 values of <5.5 and <20 mmHg s.cm, respectively, were optimal for the diagnosis of HD infants when using the solid-state HRAM system, with high diagnostic accuracies of 83.33% and 83.33%, respectively. Conclusion: ASRI may assist the diagnosis of HD infants using either water-perfused or solid-state HRAM. These systems require different catheter-specific ASRI cutoffs for the prediction of HD. |
| first_indexed | 2024-03-07T20:05:10Z |
| format | Article |
| id | doaj.art-84c5b27680a24089834f0fd9db57689e |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-07T20:05:10Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-84c5b27680a24089834f0fd9db57689e2024-02-28T05:12:48ZengElsevierJournal of the Formosan Medical Association0929-66462024-02-011232267272Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometryJia-Feng Wu0Yu-Cheng Lin1Chia-Hsiang Yang2Ping-Huei Tseng3I-Jung Tsai4Wen-Hsi Lin5Wen-Ming Hsu6Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital, No. 8, Chung-Shan S. Rd., Taipei, Taiwan. Fax: +(886-2)- 23114592.Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, TaiwanGraduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan; Department of Electrical Engineering, National Taiwan University, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Surgery, National Taiwan University Hospital, Taipei, TaiwanDepartment of Surgery, National Taiwan University Hospital, Taipei, TaiwanBackground/Purpose: We investigated the diagnostic performance of the anal sphincter relaxation integral (ASRI) for infants with Hirschsprung's disease (HD). Methods: We performed water-perfused high-resolution anorectal manometry (HRAM) in 18 infants (9 with HD), and solid-state HRAM in another 18 infants (4 with HD). We calculated the ASRI during the rectoanal inhibitory reflex (RAIR) maneuver at pressure cutoffs of <10 mmHg (ASRI 10) and <15 mmHg (ASRI 15). We investigated the diagnostic performance of the ASRI for HD in infants undergoing water-perfused and solid-state HRAM. Results: HD infants who underwent either water-perfused or solid-state HRAM had significantly lower ASRI 10 and ASRI 15 values, compared with non-HD infants (P < 0.05 and P < 0.05, respectively). Using the water-perfused HRAM system, ASRI 10 and ASRI 15 values of <7 and <29 mmHg s.cm, respectively, exhibited good diagnostic performance for HD (88.89% and 88.89%, respectively). Receiver operating characteristic curve analysis indicated that ASRI 10 and ASRI 15 values of <5.5 and <20 mmHg s.cm, respectively, were optimal for the diagnosis of HD infants when using the solid-state HRAM system, with high diagnostic accuracies of 83.33% and 83.33%, respectively. Conclusion: ASRI may assist the diagnosis of HD infants using either water-perfused or solid-state HRAM. These systems require different catheter-specific ASRI cutoffs for the prediction of HD.http://www.sciencedirect.com/science/article/pii/S0929664623003273Anal sphincter relaxation integralHirschsprung's diseaseSolid-state high-resolution anorectal manometryWater-perfused high-resolution anorectal manometry |
| spellingShingle | Jia-Feng Wu Yu-Cheng Lin Chia-Hsiang Yang Ping-Huei Tseng I-Jung Tsai Wen-Hsi Lin Wen-Ming Hsu Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry Journal of the Formosan Medical Association Anal sphincter relaxation integral Hirschsprung's disease Solid-state high-resolution anorectal manometry Water-perfused high-resolution anorectal manometry |
| title | Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry |
| title_full | Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry |
| title_fullStr | Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry |
| title_full_unstemmed | Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry |
| title_short | Clinical utility of anal sphincter relaxation integral in water-perfused and solid-state high-resolution anorectal manometry |
| title_sort | clinical utility of anal sphincter relaxation integral in water perfused and solid state high resolution anorectal manometry |
| topic | Anal sphincter relaxation integral Hirschsprung's disease Solid-state high-resolution anorectal manometry Water-perfused high-resolution anorectal manometry |
| url | http://www.sciencedirect.com/science/article/pii/S0929664623003273 |
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