Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer
Abstract Background Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | Biomarker Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40364-017-0099-2 |
| _version_ | 1828942736937451520 |
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| author | Wataru Goto Shinichiro Kashiwagi Yuka Asano Koji Takada Katsuyuki Takahashi Takaharu Hatano Tsutomu Takashima Shuhei Tomita Hisashi Motomura Masahiko Ohsawa Kosei Hirakawa Masaichi Ohira |
| author_facet | Wataru Goto Shinichiro Kashiwagi Yuka Asano Koji Takada Katsuyuki Takahashi Takaharu Hatano Tsutomu Takashima Shuhei Tomita Hisashi Motomura Masahiko Ohsawa Kosei Hirakawa Masaichi Ohira |
| author_sort | Wataru Goto |
| collection | DOAJ |
| description | Abstract Background Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer. Methods We evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy. Expression of plakoglobin was identified by immunohistochemical staining in the cell membrane. We also examined the relation between the expression of plakoglobin and E-cadherin, an epithelial–mesenchymal transition (EMT) marker. Results Patients with high plakoglobin expression had significantly worse distant-metastasis-free survival (DMFS) (P = 0.016, log rank). Plakoglobin expression had no correlation with pathological complete response rate (P = 0.627). On univariate analysis with respect to distant metastasis, high plakoglobin expression showed worse prognosis than low plakoglobin expression [P = 0.036, hazard ratio (HR) = 3.719]. Multivariate analysis found the same result (P = 0.013, HR = 5.052). In addition, there was a significant relationship between the expression of plakoglobin and E-cadherin (P = 0.023). Conclusions Plakoglobin expression is an independent prognostic factor in patients with breast cancer, particularly for DMFS, and this is related to EMT. |
| first_indexed | 2024-12-14T04:01:43Z |
| format | Article |
| id | doaj.art-84c8976f808b47138b07f66e496e27df |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-14T04:01:43Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-84c8976f808b47138b07f66e496e27df2022-12-21T23:17:56ZengBMCBiomarker Research2050-77712017-05-01511810.1186/s40364-017-0099-2Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancerWataru Goto0Shinichiro Kashiwagi1Yuka Asano2Koji Takada3Katsuyuki Takahashi4Takaharu Hatano5Tsutomu Takashima6Shuhei Tomita7Hisashi Motomura8Masahiko Ohsawa9Kosei Hirakawa10Masaichi Ohira11Department of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Pharmacology, Osaka City University Graduate School of MedicineDepartment of Plastic and Reconstructive Surgery, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Pharmacology, Osaka City University Graduate School of MedicineDepartment of Plastic and Reconstructive Surgery, Osaka City University Graduate School of MedicineDepartment of Diagnostic Pathology, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineDepartment of Surgical Oncology, Osaka City University Graduate School of MedicineAbstract Background Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer. Methods We evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy. Expression of plakoglobin was identified by immunohistochemical staining in the cell membrane. We also examined the relation between the expression of plakoglobin and E-cadherin, an epithelial–mesenchymal transition (EMT) marker. Results Patients with high plakoglobin expression had significantly worse distant-metastasis-free survival (DMFS) (P = 0.016, log rank). Plakoglobin expression had no correlation with pathological complete response rate (P = 0.627). On univariate analysis with respect to distant metastasis, high plakoglobin expression showed worse prognosis than low plakoglobin expression [P = 0.036, hazard ratio (HR) = 3.719]. Multivariate analysis found the same result (P = 0.013, HR = 5.052). In addition, there was a significant relationship between the expression of plakoglobin and E-cadherin (P = 0.023). Conclusions Plakoglobin expression is an independent prognostic factor in patients with breast cancer, particularly for DMFS, and this is related to EMT.http://link.springer.com/article/10.1186/s40364-017-0099-2PlakoglobinCirculating tumor cellsNeoadjuvant chemotherapyBreast cancerPredictive marker |
| spellingShingle | Wataru Goto Shinichiro Kashiwagi Yuka Asano Koji Takada Katsuyuki Takahashi Takaharu Hatano Tsutomu Takashima Shuhei Tomita Hisashi Motomura Masahiko Ohsawa Kosei Hirakawa Masaichi Ohira Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer Biomarker Research Plakoglobin Circulating tumor cells Neoadjuvant chemotherapy Breast cancer Predictive marker |
| title | Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| title_full | Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| title_fullStr | Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| title_full_unstemmed | Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| title_short | Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| title_sort | circulating tumor cell clusters associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer |
| topic | Plakoglobin Circulating tumor cells Neoadjuvant chemotherapy Breast cancer Predictive marker |
| url | http://link.springer.com/article/10.1186/s40364-017-0099-2 |
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