Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials
Pancreatic cancer is rising as one of the leading causes of cancer-related death worldwide. Patients often present with advanced disease, limiting curative treatment options and therefore making management of the disease difficult. Systemic chemotherapy has been an established part of the standard t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/7/499 |
| _version_ | 1797589668828545024 |
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| author | Mathilde Weisz Ejlsmark Tine Schytte Uffe Bernchou Rana Bahij Britta Weber Michael Bau Mortensen Per Pfeiffer |
| author_facet | Mathilde Weisz Ejlsmark Tine Schytte Uffe Bernchou Rana Bahij Britta Weber Michael Bau Mortensen Per Pfeiffer |
| author_sort | Mathilde Weisz Ejlsmark |
| collection | DOAJ |
| description | Pancreatic cancer is rising as one of the leading causes of cancer-related death worldwide. Patients often present with advanced disease, limiting curative treatment options and therefore making management of the disease difficult. Systemic chemotherapy has been an established part of the standard treatment in patients with both locally advanced and metastatic pancreatic cancer. In contrast, the use of radiotherapy has no clear defined role in the treatment of these patients. With the evolving imaging and radiation techniques, radiation could become a plausible intervention. In this review, we give an overview over the available data regarding radiotherapy, chemoradiation, and stereotactic body radiation therapy. We performed a systematic search of Embase and the PubMed database, focusing on studies involving locally advanced pancreatic cancer (or non-resectable pancreatic cancer) and radiotherapy without any limitation for the time of publication. We included randomised controlled trials involving patients with locally advanced pancreatic cancer, including radiotherapy, chemoradiation, or stereotactic body radiation therapy. The included articles represented mainly small patient groups and had a high heterogeneity regarding radiation delivery and modality. This review presents conflicting results concerning the addition of radiation and modality in the treatment regimen. Further research is needed to improve outcomes and define the role of radiation therapy in pancreatic cancer. |
| first_indexed | 2024-03-11T01:09:49Z |
| format | Article |
| id | doaj.art-84c8ef3ae4404d2e855f9ea004735ac8 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T01:09:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-84c8ef3ae4404d2e855f9ea004735ac82023-11-18T18:56:08ZengMDPI AGCurrent Oncology1198-00521718-77292023-07-013076820683710.3390/curroncol30070499Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised TrialsMathilde Weisz Ejlsmark0Tine Schytte1Uffe Bernchou2Rana Bahij3Britta Weber4Michael Bau Mortensen5Per Pfeiffer6Department of Oncology, Odense University Hospital, 5000 Odense, DenmarkDepartment of Oncology, Odense University Hospital, 5000 Odense, DenmarkDepartment of Clinical Research, University of Southern Denmark, 5000 Odense, DenmarkDepartment of Oncology, Odense University Hospital, 5000 Odense, DenmarkDepartment of Oncology, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Clinical Research, University of Southern Denmark, 5000 Odense, DenmarkDepartment of Oncology, Odense University Hospital, 5000 Odense, DenmarkPancreatic cancer is rising as one of the leading causes of cancer-related death worldwide. Patients often present with advanced disease, limiting curative treatment options and therefore making management of the disease difficult. Systemic chemotherapy has been an established part of the standard treatment in patients with both locally advanced and metastatic pancreatic cancer. In contrast, the use of radiotherapy has no clear defined role in the treatment of these patients. With the evolving imaging and radiation techniques, radiation could become a plausible intervention. In this review, we give an overview over the available data regarding radiotherapy, chemoradiation, and stereotactic body radiation therapy. We performed a systematic search of Embase and the PubMed database, focusing on studies involving locally advanced pancreatic cancer (or non-resectable pancreatic cancer) and radiotherapy without any limitation for the time of publication. We included randomised controlled trials involving patients with locally advanced pancreatic cancer, including radiotherapy, chemoradiation, or stereotactic body radiation therapy. The included articles represented mainly small patient groups and had a high heterogeneity regarding radiation delivery and modality. This review presents conflicting results concerning the addition of radiation and modality in the treatment regimen. Further research is needed to improve outcomes and define the role of radiation therapy in pancreatic cancer.https://www.mdpi.com/1718-7729/30/7/499pancreatic adenocarcinomaradiotherapychemoradiationstereotactic body radiation therapyablative radiotherapyMR-guided radiation therapy |
| spellingShingle | Mathilde Weisz Ejlsmark Tine Schytte Uffe Bernchou Rana Bahij Britta Weber Michael Bau Mortensen Per Pfeiffer Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials Current Oncology pancreatic adenocarcinoma radiotherapy chemoradiation stereotactic body radiation therapy ablative radiotherapy MR-guided radiation therapy |
| title | Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials |
| title_full | Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials |
| title_fullStr | Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials |
| title_full_unstemmed | Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials |
| title_short | Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials |
| title_sort | radiotherapy for locally advanced pancreatic adenocarcinoma a critical review of randomised trials |
| topic | pancreatic adenocarcinoma radiotherapy chemoradiation stereotactic body radiation therapy ablative radiotherapy MR-guided radiation therapy |
| url | https://www.mdpi.com/1718-7729/30/7/499 |
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