Cancer stem cells in brain tumors: From origin to clinical implications
Abstract Malignant brain tumors are highly heterogeneous tumors with a poor prognosis and a high morbidity and mortality rate in both children and adults. The cancer stem cell (CSC, also named tumor‐initiating cell) model states that tumor growth is driven by a subset of CSCs. This model explains so...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.341 |
| _version_ | 1797693080300683264 |
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| author | Shuyun Lin Kaishu Li Ling Qi |
| author_facet | Shuyun Lin Kaishu Li Ling Qi |
| author_sort | Shuyun Lin |
| collection | DOAJ |
| description | Abstract Malignant brain tumors are highly heterogeneous tumors with a poor prognosis and a high morbidity and mortality rate in both children and adults. The cancer stem cell (CSC, also named tumor‐initiating cell) model states that tumor growth is driven by a subset of CSCs. This model explains some of the clinical observations of brain tumors, including the almost unavoidable tumor recurrence after initial successful chemotherapy and/or radiotherapy and treatment resistance. Over the past two decades, strategies for the identification and characterization of brain CSCs have improved significantly, supporting the design of new diagnostic and therapeutic strategies for brain tumors. Relevant studies have unveiled novel characteristics of CSCs in the brain, including their heterogeneity and distinctive immunobiology, which have provided opportunities for new research directions and potential therapeutic approaches. In this review, we summarize the current knowledge of CSCs markers and stemness regulators in brain tumors. We also comprehensively describe the influence of the CSCs niche and tumor microenvironment on brain tumor stemness, including interactions between CSCs and the immune system, and discuss the potential application of CSCs in brain‐based therapies for the treatment of brain tumors. |
| first_indexed | 2024-03-12T02:38:24Z |
| format | Article |
| id | doaj.art-84c9443ba1c44999911158a9c367f3fc |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-12T02:38:24Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-84c9443ba1c44999911158a9c367f3fc2023-09-04T11:20:36ZengWileyMedComm2688-26632023-08-0144n/an/a10.1002/mco2.341Cancer stem cells in brain tumors: From origin to clinical implicationsShuyun Lin0Kaishu Li1Ling Qi2Institute of Digestive DiseaseThe Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuanGuangdongChinaInstitute of Digestive DiseaseThe Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuanGuangdongChinaInstitute of Digestive DiseaseThe Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuanGuangdongChinaAbstract Malignant brain tumors are highly heterogeneous tumors with a poor prognosis and a high morbidity and mortality rate in both children and adults. The cancer stem cell (CSC, also named tumor‐initiating cell) model states that tumor growth is driven by a subset of CSCs. This model explains some of the clinical observations of brain tumors, including the almost unavoidable tumor recurrence after initial successful chemotherapy and/or radiotherapy and treatment resistance. Over the past two decades, strategies for the identification and characterization of brain CSCs have improved significantly, supporting the design of new diagnostic and therapeutic strategies for brain tumors. Relevant studies have unveiled novel characteristics of CSCs in the brain, including their heterogeneity and distinctive immunobiology, which have provided opportunities for new research directions and potential therapeutic approaches. In this review, we summarize the current knowledge of CSCs markers and stemness regulators in brain tumors. We also comprehensively describe the influence of the CSCs niche and tumor microenvironment on brain tumor stemness, including interactions between CSCs and the immune system, and discuss the potential application of CSCs in brain‐based therapies for the treatment of brain tumors.https://doi.org/10.1002/mco2.341brain tumorscancer stem cellscell of originclinical implicationsimmune systemstemness regulators |
| spellingShingle | Shuyun Lin Kaishu Li Ling Qi Cancer stem cells in brain tumors: From origin to clinical implications MedComm brain tumors cancer stem cells cell of origin clinical implications immune system stemness regulators |
| title | Cancer stem cells in brain tumors: From origin to clinical implications |
| title_full | Cancer stem cells in brain tumors: From origin to clinical implications |
| title_fullStr | Cancer stem cells in brain tumors: From origin to clinical implications |
| title_full_unstemmed | Cancer stem cells in brain tumors: From origin to clinical implications |
| title_short | Cancer stem cells in brain tumors: From origin to clinical implications |
| title_sort | cancer stem cells in brain tumors from origin to clinical implications |
| topic | brain tumors cancer stem cells cell of origin clinical implications immune system stemness regulators |
| url | https://doi.org/10.1002/mco2.341 |
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