Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, whic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-10-01
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| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221175391400044X |
| _version_ | 1818279282377490432 |
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| author | Jia Chen Feng Chen Ying Wang Ling-Yi Yang Miao Miao Yue Han De-Pei Wu |
| author_facet | Jia Chen Feng Chen Ying Wang Ling-Yi Yang Miao Miao Yue Han De-Pei Wu |
| author_sort | Jia Chen |
| collection | DOAJ |
| description | Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin – in which liposomal AmB dose was reduced due to renal toxicity – was administered to successfully treat this patient. |
| first_indexed | 2024-12-12T23:30:51Z |
| format | Article |
| id | doaj.art-84ca0de7fdb84f67acb2d9956d699010 |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-12-12T23:30:51Z |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-84ca0de7fdb84f67acb2d9956d6990102022-12-22T00:07:47ZengElsevierMedical Mycology Case Reports2211-75392014-10-016C555710.1016/j.mmcr.2014.09.003Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazoleJia Chen0Feng Chen1Ying Wang2Ling-Yi Yang3Miao Miao4Yue Han5De-Pei Wu6Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaRespiratory Department, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaTrichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin – in which liposomal AmB dose was reduced due to renal toxicity – was administered to successfully treat this patient.http://www.sciencedirect.com/science/article/pii/S221175391400044XT. asahiiLiposomal amphotericin BCaspofunginVoriconazole |
| spellingShingle | Jia Chen Feng Chen Ying Wang Ling-Yi Yang Miao Miao Yue Han De-Pei Wu Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole Medical Mycology Case Reports T. asahii Liposomal amphotericin B Caspofungin Voriconazole |
| title | Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| title_full | Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| title_fullStr | Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| title_full_unstemmed | Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| title_short | Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| title_sort | use of combination therapy to successfully treat breakthrough trichosporon asahii infection in an acute leukemia patient receiving voriconazole |
| topic | T. asahii Liposomal amphotericin B Caspofungin Voriconazole |
| url | http://www.sciencedirect.com/science/article/pii/S221175391400044X |
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