Chemotherapeutic Interventions Against Tuberculosis
Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8247/5/7/690 |
| _version_ | 1811325540419764224 |
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| author | Neeraj Shakya Gaurav Garg Babita Agrawal Rakesh Kumar |
| author_facet | Neeraj Shakya Gaurav Garg Babita Agrawal Rakesh Kumar |
| author_sort | Neeraj Shakya |
| collection | DOAJ |
| description | Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by serious side effects, drug interactions and long-term administration. This has prompted urgent research efforts in the discovery and development of new anti-tuberculosis agent(s). Several families of compounds are currently being explored for the treatment of tuberculosis. This review article presents an account of the existing chemotherapeutics and highlights the therapeutic potential of emerging molecules that are at different stages of development for the management of tuberculosis disease. |
| first_indexed | 2024-04-13T14:35:00Z |
| format | Article |
| id | doaj.art-84ca5e3746624dfaacd4230e25a81d48 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-13T14:35:00Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-84ca5e3746624dfaacd4230e25a81d482022-12-22T02:43:04ZengMDPI AGPharmaceuticals1424-82472012-06-015769071810.3390/ph5070690Chemotherapeutic Interventions Against TuberculosisNeeraj ShakyaGaurav GargBabita AgrawalRakesh KumarTuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by serious side effects, drug interactions and long-term administration. This has prompted urgent research efforts in the discovery and development of new anti-tuberculosis agent(s). Several families of compounds are currently being explored for the treatment of tuberculosis. This review article presents an account of the existing chemotherapeutics and highlights the therapeutic potential of emerging molecules that are at different stages of development for the management of tuberculosis disease.http://www.mdpi.com/1424-8247/5/7/690tuberculosis chemotherapymycobacteriumdrug-resistant tuberculosisemerging TB drugs |
| spellingShingle | Neeraj Shakya Gaurav Garg Babita Agrawal Rakesh Kumar Chemotherapeutic Interventions Against Tuberculosis Pharmaceuticals tuberculosis chemotherapy mycobacterium drug-resistant tuberculosis emerging TB drugs |
| title | Chemotherapeutic Interventions Against Tuberculosis |
| title_full | Chemotherapeutic Interventions Against Tuberculosis |
| title_fullStr | Chemotherapeutic Interventions Against Tuberculosis |
| title_full_unstemmed | Chemotherapeutic Interventions Against Tuberculosis |
| title_short | Chemotherapeutic Interventions Against Tuberculosis |
| title_sort | chemotherapeutic interventions against tuberculosis |
| topic | tuberculosis chemotherapy mycobacterium drug-resistant tuberculosis emerging TB drugs |
| url | http://www.mdpi.com/1424-8247/5/7/690 |
| work_keys_str_mv | AT neerajshakya chemotherapeuticinterventionsagainsttuberculosis AT gauravgarg chemotherapeuticinterventionsagainsttuberculosis AT babitaagrawal chemotherapeuticinterventionsagainsttuberculosis AT rakeshkumar chemotherapeuticinterventionsagainsttuberculosis |