Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study
Di-Hui Lan,1 Yue Zhang,1 Bing Hua,1 Jin-Shui Li,2 Yi He,2 Hui Chen,1 Wei-Ping Li,1,3 Hong-Wei Li1,3 1Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Friendship Hospital, C...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-obesity-on-microvascular-obstruction-and-area-at-risk-in-pat-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797935625856352256 |
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| author | Lan DH Zhang Y Hua B Li JS He Y Chen H Li WP Li HW |
| author_facet | Lan DH Zhang Y Hua B Li JS He Y Chen H Li WP Li HW |
| author_sort | Lan DH |
| collection | DOAJ |
| description | Di-Hui Lan,1 Yue Zhang,1 Bing Hua,1 Jin-Shui Li,2 Yi He,2 Hui Chen,1 Wei-Ping Li,1,3 Hong-Wei Li1,3 1Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, People’s Republic of ChinaCorrespondence: Wei-Ping Li; Hong-Wei Li, Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, People’s Republic of China, Email xueer09@163.com; lhw19656@sina.comBackground: Better survival for overweight and obese patients after ST-segment elevation myocardial infarction (STEMI) has been demonstrated. The association between body mass index (BMI), microvascular obstruction (MVO), and area at risk (AAR) after STEMI was evaluated.Methods: A prospective observational study was performed to enrolled patients undergoing primary percutaneous coronary intervention (pPCI) for STEMI and cardiac magnetic resonance was performed within 5– 7 days. Patients were classified as normal weight (18.5 ≤BMI < 24.0 kg/m2), overweight (24.0 ≤BMI < 28.0 kg/m2), or obese (BMI ≥ 28 kg/m2).Results: Among 225 patients undergoing pPCI, 67 (30.00%) were normal weight, 113 (50.22%) were overweight, and 45 (20.00%) were obese. BMI ≥ 28 kg/m2 was significantly associated with less risk of MVO when compared with a normal BMI after multivariable adjustment (overweight: HR 0.29, 95% CI 0.13– 0.68, p = 0.004). Compared with normal weight patients, obese and overweight patients tend to have larger hearts (greater left ventricular end-diastolic volume [LVEDV] and left ventricular [LV] mass). In adjusted analysis, increased BMI was significantly associated with a smaller AAR. In addition, obese patients had a smaller AAR (β = − 0.252, 95% CI − 20.298- − 3.244, p = 0.007) and AAR, % LV mass (β = − 0.331, 95% CI − 0.211- − 0.062, p < 0.001) than normal weight patients.Conclusion: Obesity (BMI ≥ 28 kg/m2) is independently associated with lower risks of MVO and a smaller AAR, % LV mass than normal weight patients among subjects undergoing pPCI for STEMI.Keywords: ST-segment elevation myocardial infarction, STEMI, microvascular obstruction, MVO, cardiac magnetic resonance, CMR, body mass index, BMI, area at risk, AAR |
| first_indexed | 2024-04-10T18:17:02Z |
| format | Article |
| id | doaj.art-84cbef17247d4db5becdd4b93cbe361b |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:17:02Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-84cbef17247d4db5becdd4b93cbe361b2023-02-02T08:20:12ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-07-01Volume 152207221676885Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging StudyLan DHZhang YHua BLi JSHe YChen HLi WPLi HWDi-Hui Lan,1 Yue Zhang,1 Bing Hua,1 Jin-Shui Li,2 Yi He,2 Hui Chen,1 Wei-Ping Li,1,3 Hong-Wei Li1,3 1Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, People’s Republic of ChinaCorrespondence: Wei-Ping Li; Hong-Wei Li, Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, People’s Republic of China, Email xueer09@163.com; lhw19656@sina.comBackground: Better survival for overweight and obese patients after ST-segment elevation myocardial infarction (STEMI) has been demonstrated. The association between body mass index (BMI), microvascular obstruction (MVO), and area at risk (AAR) after STEMI was evaluated.Methods: A prospective observational study was performed to enrolled patients undergoing primary percutaneous coronary intervention (pPCI) for STEMI and cardiac magnetic resonance was performed within 5– 7 days. Patients were classified as normal weight (18.5 ≤BMI < 24.0 kg/m2), overweight (24.0 ≤BMI < 28.0 kg/m2), or obese (BMI ≥ 28 kg/m2).Results: Among 225 patients undergoing pPCI, 67 (30.00%) were normal weight, 113 (50.22%) were overweight, and 45 (20.00%) were obese. BMI ≥ 28 kg/m2 was significantly associated with less risk of MVO when compared with a normal BMI after multivariable adjustment (overweight: HR 0.29, 95% CI 0.13– 0.68, p = 0.004). Compared with normal weight patients, obese and overweight patients tend to have larger hearts (greater left ventricular end-diastolic volume [LVEDV] and left ventricular [LV] mass). In adjusted analysis, increased BMI was significantly associated with a smaller AAR. In addition, obese patients had a smaller AAR (β = − 0.252, 95% CI − 20.298- − 3.244, p = 0.007) and AAR, % LV mass (β = − 0.331, 95% CI − 0.211- − 0.062, p < 0.001) than normal weight patients.Conclusion: Obesity (BMI ≥ 28 kg/m2) is independently associated with lower risks of MVO and a smaller AAR, % LV mass than normal weight patients among subjects undergoing pPCI for STEMI.Keywords: ST-segment elevation myocardial infarction, STEMI, microvascular obstruction, MVO, cardiac magnetic resonance, CMR, body mass index, BMI, area at risk, AARhttps://www.dovepress.com/impact-of-obesity-on-microvascular-obstruction-and-area-at-risk-in-pat-peer-reviewed-fulltext-article-DMSOst-segment elevation myocardial infarction (stemi)microvascular obstruction (mvo)cardiac magnetic resonance (cmr)body mass index (bmi)area at riak (aar) |
| spellingShingle | Lan DH Zhang Y Hua B Li JS He Y Chen H Li WP Li HW Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study Diabetes, Metabolic Syndrome and Obesity st-segment elevation myocardial infarction (stemi) microvascular obstruction (mvo) cardiac magnetic resonance (cmr) body mass index (bmi) area at riak (aar) |
| title | Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study |
| title_full | Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study |
| title_fullStr | Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study |
| title_full_unstemmed | Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study |
| title_short | Impact of Obesity on Microvascular Obstruction and Area at Risk in Patients After ST-Segment-Elevation Myocardial Infarction: A Magnetic Resonance Imaging Study |
| title_sort | impact of obesity on microvascular obstruction and area at risk in patients after st segment elevation myocardial infarction a magnetic resonance imaging study |
| topic | st-segment elevation myocardial infarction (stemi) microvascular obstruction (mvo) cardiac magnetic resonance (cmr) body mass index (bmi) area at riak (aar) |
| url | https://www.dovepress.com/impact-of-obesity-on-microvascular-obstruction-and-area-at-risk-in-pat-peer-reviewed-fulltext-article-DMSO |
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