Interferon Family Cytokines in Obesity and Insulin Sensitivity
Obesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/4041 |
| _version_ | 1797460953104646144 |
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| author | Ling-Yu Huang Chiao-Juno Chiu Chung-Hsi Hsing Yu-Hsiang Hsu |
| author_facet | Ling-Yu Huang Chiao-Juno Chiu Chung-Hsi Hsing Yu-Hsiang Hsu |
| author_sort | Ling-Yu Huang |
| collection | DOAJ |
| description | Obesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic dysfunction. Infiltrated immune cells, adipocytes, and stromal cells are all involved in the production of proinflammatory cytokines and chemokines in adipose tissues and affect systemic homeostasis. Interferons (IFNs) are a large family of pleiotropic cytokines that play a pivotal role in host antiviral defenses. IFNs are critical immune modulators in response to pathogens, dead cells, and several inflammation-mediated diseases. Several studies have indicated that IFNs are involved in the pathogenesis of obesity. In this review, we discuss the roles of IFN family cytokines in the development of obesity-induced inflammation and insulin resistance. |
| first_indexed | 2024-03-09T17:12:29Z |
| format | Article |
| id | doaj.art-84cec9dae0a34724aa3171fc304e251b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:12:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-84cec9dae0a34724aa3171fc304e251b2023-11-24T13:54:49ZengMDPI AGCells2073-44092022-12-011124404110.3390/cells11244041Interferon Family Cytokines in Obesity and Insulin SensitivityLing-Yu Huang0Chiao-Juno Chiu1Chung-Hsi Hsing2Yu-Hsiang Hsu3Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanDepartment of Medical Research, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Anesthesiology, Chi Mei Medical Center, Tainan 710, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanObesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic dysfunction. Infiltrated immune cells, adipocytes, and stromal cells are all involved in the production of proinflammatory cytokines and chemokines in adipose tissues and affect systemic homeostasis. Interferons (IFNs) are a large family of pleiotropic cytokines that play a pivotal role in host antiviral defenses. IFNs are critical immune modulators in response to pathogens, dead cells, and several inflammation-mediated diseases. Several studies have indicated that IFNs are involved in the pathogenesis of obesity. In this review, we discuss the roles of IFN family cytokines in the development of obesity-induced inflammation and insulin resistance.https://www.mdpi.com/2073-4409/11/24/4041obesityinterferoninsulin resistance |
| spellingShingle | Ling-Yu Huang Chiao-Juno Chiu Chung-Hsi Hsing Yu-Hsiang Hsu Interferon Family Cytokines in Obesity and Insulin Sensitivity Cells obesity interferon insulin resistance |
| title | Interferon Family Cytokines in Obesity and Insulin Sensitivity |
| title_full | Interferon Family Cytokines in Obesity and Insulin Sensitivity |
| title_fullStr | Interferon Family Cytokines in Obesity and Insulin Sensitivity |
| title_full_unstemmed | Interferon Family Cytokines in Obesity and Insulin Sensitivity |
| title_short | Interferon Family Cytokines in Obesity and Insulin Sensitivity |
| title_sort | interferon family cytokines in obesity and insulin sensitivity |
| topic | obesity interferon insulin resistance |
| url | https://www.mdpi.com/2073-4409/11/24/4041 |
| work_keys_str_mv | AT lingyuhuang interferonfamilycytokinesinobesityandinsulinsensitivity AT chiaojunochiu interferonfamilycytokinesinobesityandinsulinsensitivity AT chunghsihsing interferonfamilycytokinesinobesityandinsulinsensitivity AT yuhsianghsu interferonfamilycytokinesinobesityandinsulinsensitivity |