Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis
ObjectiveTo investigate the correlation between prognosis and intracranial carotid artery calcification (ICAC) in patients with acute ischemic stroke (AIS) who receive intravenous thrombolysis (IVT).MethodsA total of 156 AIS patients who received IVT from March 2019 to March 2020 were enrolled. The...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.740656/full |
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| author | Yuan Shen Yuan Shen Yuan Shen Zhifeng Dong Gang Xu Jianguo Zhong Pinglei Pan Zhipeng Chen Haicun Shi Haicun Shi Haicun Shi |
| author_facet | Yuan Shen Yuan Shen Yuan Shen Zhifeng Dong Gang Xu Jianguo Zhong Pinglei Pan Zhipeng Chen Haicun Shi Haicun Shi Haicun Shi |
| author_sort | Yuan Shen |
| collection | DOAJ |
| description | ObjectiveTo investigate the correlation between prognosis and intracranial carotid artery calcification (ICAC) in patients with acute ischemic stroke (AIS) who receive intravenous thrombolysis (IVT).MethodsA total of 156 AIS patients who received IVT from March 2019 to March 2020 were enrolled. The modified Woodcock visual score was used to evaluate ICAC in nonenhanced head CT scans. Patients were divided into high calcification burden (HCB; score ≥3) and low calcification burden (LCB; score <3) groups. Demographic, laboratory, imaging and clinical data were compared between the two groups, and whether HCB was a prognostic factor was evaluated.ResultsCompared with the LCB group, the HCB group had a higher incidence of atrial fibrillation (49.2 vs.22.1%, P < 0.001) and coronary heart disease (24.6 vs. 10.0%, P = 0.019) and higher serum homocysteine [15.31 (12.15, 17.50) vs. 14.40 (11.20, 16.20), P = 0.036] and hemoglobin A1c (6.93 ± 1.77 vs. 6.37 ± 0.74, P = 0.023) levels. Binary logistic regression analysis showed that atrial fibrillation (OR = 3.031, 95% CI: 1.312–7.006, P = 0.009) and HbA1c (OR = 1.488, 95% CI: 1.050–2.109, P = 0.026) were independent risk factors for ICAC. After adjusting for other risk factors, symptomatic-side and bilateral ICACs were independent risk factors for poor prognosis (OR = 1.969, 95% CI: 1.220–3.178, P = 0.006), (OR = 1.354, 95% CI: 1.065–1.722, P = 0.013) and mortality (OR = 4.245, 95% CI: 1.114–16.171, P = 0.034), (OR = 2.414, 95% CI = 1.152–5.060, P = 0.020) in patients with AIS who received IVT.ConclusionICAC is closely related to the prognosis of acute ischemic stroke after intravenous thrombolysis. |
| first_indexed | 2024-04-14T07:46:10Z |
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| id | doaj.art-84cef6e38229468f8b663db11d32b40f |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-14T07:46:10Z |
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| spelling | doaj.art-84cef6e38229468f8b663db11d32b40f2022-12-22T02:05:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-04-011310.3389/fneur.2022.740656740656Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous ThrombolysisYuan Shen0Yuan Shen1Yuan Shen2Zhifeng Dong3Gang Xu4Jianguo Zhong5Pinglei Pan6Zhipeng Chen7Haicun Shi8Haicun Shi9Haicun Shi10Department of Neurology, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Neurology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, ChinaThe Sixth Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Medical Imaging, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Neurology, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Central Laboratory, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Neurology, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Neurology, Yancheng Third People's Hospital, Yancheng, ChinaDepartment of Neurology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, ChinaThe Sixth Affiliated Hospital of Nantong University, Nantong, ChinaObjectiveTo investigate the correlation between prognosis and intracranial carotid artery calcification (ICAC) in patients with acute ischemic stroke (AIS) who receive intravenous thrombolysis (IVT).MethodsA total of 156 AIS patients who received IVT from March 2019 to March 2020 were enrolled. The modified Woodcock visual score was used to evaluate ICAC in nonenhanced head CT scans. Patients were divided into high calcification burden (HCB; score ≥3) and low calcification burden (LCB; score <3) groups. Demographic, laboratory, imaging and clinical data were compared between the two groups, and whether HCB was a prognostic factor was evaluated.ResultsCompared with the LCB group, the HCB group had a higher incidence of atrial fibrillation (49.2 vs.22.1%, P < 0.001) and coronary heart disease (24.6 vs. 10.0%, P = 0.019) and higher serum homocysteine [15.31 (12.15, 17.50) vs. 14.40 (11.20, 16.20), P = 0.036] and hemoglobin A1c (6.93 ± 1.77 vs. 6.37 ± 0.74, P = 0.023) levels. Binary logistic regression analysis showed that atrial fibrillation (OR = 3.031, 95% CI: 1.312–7.006, P = 0.009) and HbA1c (OR = 1.488, 95% CI: 1.050–2.109, P = 0.026) were independent risk factors for ICAC. After adjusting for other risk factors, symptomatic-side and bilateral ICACs were independent risk factors for poor prognosis (OR = 1.969, 95% CI: 1.220–3.178, P = 0.006), (OR = 1.354, 95% CI: 1.065–1.722, P = 0.013) and mortality (OR = 4.245, 95% CI: 1.114–16.171, P = 0.034), (OR = 2.414, 95% CI = 1.152–5.060, P = 0.020) in patients with AIS who received IVT.ConclusionICAC is closely related to the prognosis of acute ischemic stroke after intravenous thrombolysis.https://www.frontiersin.org/articles/10.3389/fneur.2022.740656/fullacute strokecalcificationprognosiscarotid arteryintravenous thrombolysis |
| spellingShingle | Yuan Shen Yuan Shen Yuan Shen Zhifeng Dong Gang Xu Jianguo Zhong Pinglei Pan Zhipeng Chen Haicun Shi Haicun Shi Haicun Shi Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis Frontiers in Neurology acute stroke calcification prognosis carotid artery intravenous thrombolysis |
| title | Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis |
| title_full | Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis |
| title_fullStr | Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis |
| title_full_unstemmed | Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis |
| title_short | Correlation Between Intracranial Carotid Artery Calcification and Prognosis of Acute Ischemic Stroke After Intravenous Thrombolysis |
| title_sort | correlation between intracranial carotid artery calcification and prognosis of acute ischemic stroke after intravenous thrombolysis |
| topic | acute stroke calcification prognosis carotid artery intravenous thrombolysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.740656/full |
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