Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study
ObjectiveTo explore the effect of moxa cone moxibustion on N-acetyl aspartate/total creatinine (NAA/tCr) and choline/total creatinine (Cho/tCr) in the bilateral hippocampus (HIP) and bilateral posterior cingulate gyrus (PCG) in patients with mild cognitive impairment (MCI) using hydrogen proton magn...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.773687/full |
| _version_ | 1828217137410342912 |
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| author | Wei Mai Wei Mai Aizhen Zhang Qiang Liu Liying Tang Yichen Wei Jiahui Su Gaoxiong Duan Jinlong Teng Xiucheng Nong Bihan Yu Chong Li Lijuan Shao Demao Deng Shangjie Chen Lihua Zhao |
| author_facet | Wei Mai Wei Mai Aizhen Zhang Qiang Liu Liying Tang Yichen Wei Jiahui Su Gaoxiong Duan Jinlong Teng Xiucheng Nong Bihan Yu Chong Li Lijuan Shao Demao Deng Shangjie Chen Lihua Zhao |
| author_sort | Wei Mai |
| collection | DOAJ |
| description | ObjectiveTo explore the effect of moxa cone moxibustion on N-acetyl aspartate/total creatinine (NAA/tCr) and choline/total creatinine (Cho/tCr) in the bilateral hippocampus (HIP) and bilateral posterior cingulate gyrus (PCG) in patients with mild cognitive impairment (MCI) using hydrogen proton magnetic resonance spectroscopy (1H-MRS) and to provide imaging basis for moxa cone moxibustion treatment for MCI.MethodsOne hundred eight patients with MCI were served as the MCI group, and 67 age-matched subjects were enrolled as the normal control group. The MCI group was randomized and allocated into acupoint group, drug group, and sham acupoint group, with 36 cases in each group. Some patients in each group withdrew. Finally, 25 cases were included in the acupoint group, 24 cases in the drug group, and 20 cases in the sham acupoint group. The drug group was treated with oral donepezil hydrochloride. The acupoint group and sham acupoint group received moxa cone moxibustion treatment. Mini-mental state exam (MMSE) and Montreal cognitive assessment (MoCA) scores were recorded before intervention, at the end of the first and the second months of intervention, and in the 5th month of follow-up. The NAA/tCr and Cho/tCr ratios in the HIP and PCG were bilaterally measured by 1H-MRS before and after intervention.ResultsBefore intervention, compared with the normal control group, the MMSE and MoCA scores, the Cho/tCr ratio in the right HIP, the NAA/tCr ratio in the bilateral HIP, and the NAA/tCr ratio in the left PCG in the three treatment groups decreased significantly (both p < 0.01), and the NAA/tCr ratio in the right PCG significantly reduced in the acupoint and drug groups (p < 0.05). After two months of treatment, compared with the normal control group, there were no differences in the MoCA scores, the NAA/tCr, and Cho/tCr ratios in the bilateral PCG and bilateral HIP in the three treatment groups (p > 0.05). However, the MMSE scores in the drug group decreased when compared with the acupoint group and normal control group (p < 0.05, p < 0.01). The scores of MMSE and MoCA in the acupoint group and sham acupoint group at all time points were better than those in the drug group, which were similar to those in the normal control group.ConclusionOur findings suggest that moxibustion could improve the cognitive function of patients with MCI. The mechanism may be related to the improvement of abnormal brain metabolism in HIP and PCG. |
| first_indexed | 2024-04-12T15:42:08Z |
| format | Article |
| id | doaj.art-84cfda6af5894137b3a95add99b05343 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T15:42:08Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-84cfda6af5894137b3a95add99b053432022-12-22T03:26:45ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.773687773687Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS StudyWei Mai0Wei Mai1Aizhen Zhang2Qiang Liu3Liying Tang4Yichen Wei5Jiahui Su6Gaoxiong Duan7Jinlong Teng8Xiucheng Nong9Bihan Yu10Chong Li11Lijuan Shao12Demao Deng13Shangjie Chen14Lihua Zhao15Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Traditional Chinese Medicine, Guangxi Tumour Hospital, Nanning, ChinaGuangxi Medical College, Nanning, ChinaXinghu Outpatient Department, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaXinghu Outpatient Department, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Radiology, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Radiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaDepartment of Radiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Rehabilitation, The Second Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Acupuncture, The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, ChinaObjectiveTo explore the effect of moxa cone moxibustion on N-acetyl aspartate/total creatinine (NAA/tCr) and choline/total creatinine (Cho/tCr) in the bilateral hippocampus (HIP) and bilateral posterior cingulate gyrus (PCG) in patients with mild cognitive impairment (MCI) using hydrogen proton magnetic resonance spectroscopy (1H-MRS) and to provide imaging basis for moxa cone moxibustion treatment for MCI.MethodsOne hundred eight patients with MCI were served as the MCI group, and 67 age-matched subjects were enrolled as the normal control group. The MCI group was randomized and allocated into acupoint group, drug group, and sham acupoint group, with 36 cases in each group. Some patients in each group withdrew. Finally, 25 cases were included in the acupoint group, 24 cases in the drug group, and 20 cases in the sham acupoint group. The drug group was treated with oral donepezil hydrochloride. The acupoint group and sham acupoint group received moxa cone moxibustion treatment. Mini-mental state exam (MMSE) and Montreal cognitive assessment (MoCA) scores were recorded before intervention, at the end of the first and the second months of intervention, and in the 5th month of follow-up. The NAA/tCr and Cho/tCr ratios in the HIP and PCG were bilaterally measured by 1H-MRS before and after intervention.ResultsBefore intervention, compared with the normal control group, the MMSE and MoCA scores, the Cho/tCr ratio in the right HIP, the NAA/tCr ratio in the bilateral HIP, and the NAA/tCr ratio in the left PCG in the three treatment groups decreased significantly (both p < 0.01), and the NAA/tCr ratio in the right PCG significantly reduced in the acupoint and drug groups (p < 0.05). After two months of treatment, compared with the normal control group, there were no differences in the MoCA scores, the NAA/tCr, and Cho/tCr ratios in the bilateral PCG and bilateral HIP in the three treatment groups (p > 0.05). However, the MMSE scores in the drug group decreased when compared with the acupoint group and normal control group (p < 0.05, p < 0.01). The scores of MMSE and MoCA in the acupoint group and sham acupoint group at all time points were better than those in the drug group, which were similar to those in the normal control group.ConclusionOur findings suggest that moxibustion could improve the cognitive function of patients with MCI. The mechanism may be related to the improvement of abnormal brain metabolism in HIP and PCG.https://www.frontiersin.org/articles/10.3389/fnagi.2022.773687/fullmoxa cone moxibustionhydrogen proton magnetic resonance spectroscopy (1H-MRS)mild cognitive impairment (MCI)metabolitescognitive functionhippocampus |
| spellingShingle | Wei Mai Wei Mai Aizhen Zhang Qiang Liu Liying Tang Yichen Wei Jiahui Su Gaoxiong Duan Jinlong Teng Xiucheng Nong Bihan Yu Chong Li Lijuan Shao Demao Deng Shangjie Chen Lihua Zhao Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study Frontiers in Aging Neuroscience moxa cone moxibustion hydrogen proton magnetic resonance spectroscopy (1H-MRS) mild cognitive impairment (MCI) metabolites cognitive function hippocampus |
| title | Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study |
| title_full | Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study |
| title_fullStr | Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study |
| title_full_unstemmed | Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study |
| title_short | Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study |
| title_sort | effects of moxa cone moxibustion therapy on cognitive function and brain metabolic changes in mci patients a pilot 1h mrs study |
| topic | moxa cone moxibustion hydrogen proton magnetic resonance spectroscopy (1H-MRS) mild cognitive impairment (MCI) metabolites cognitive function hippocampus |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.773687/full |
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