Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia
Takashi Ohnishi,1 Akihide Wakamatsu,1 Hisanori Kobayashi2 1Medical Affairs Division, Janssen Pharmaceutical K.K., Tokyo, Japan; 2Research and Development Clinical Science Division, Janssen Pharmaceutical K.K., Tokyo, JapanCorrespondence: Takashi OhnishiMedical Affairs Division, Janssen Pharmaceutica...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-04-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/early-improvement-of-psychiatric-symptoms-with-long-acting-injectable--peer-reviewed-article-NDT |
| _version_ | 1818343849631678464 |
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| author | Ohnishi T Wakamatsu A Kobayashi H |
| author_facet | Ohnishi T Wakamatsu A Kobayashi H |
| author_sort | Ohnishi T |
| collection | DOAJ |
| description | Takashi Ohnishi,1 Akihide Wakamatsu,1 Hisanori Kobayashi2 1Medical Affairs Division, Janssen Pharmaceutical K.K., Tokyo, Japan; 2Research and Development Clinical Science Division, Janssen Pharmaceutical K.K., Tokyo, JapanCorrespondence: Takashi OhnishiMedical Affairs Division, Janssen Pharmaceutical K.K., 5-2, Nishi-kanda 3-chome Chiyoda-ku, Tokyo, 101-0065, JapanTel +81-3-4411-7700Fax +81-3-4411– 5031Email tohnish8@its.jnj.comPurpose: The aim of this study was to clarify whether early symptomatic improvement in response to a long-acting injectable antipsychotic (LAI) contributes to subsequent social functional remission in patients with schizophrenia using the previous clinical trial data (EudraCT registration number: 2011-004889-15). Associations between other factors and social functional remission were also explored.Patients and Methods: We analyzed 428 patients with schizophrenia in which the personal and social performance scale (PSP) and the involvement evaluation questionnaire (IEQ) at the time of the base line were recorded. Social functional remission was defined as participants who scored PSP > 70 at the end of 65 weeks. Logistic regression analyses were done to examine associations between social functional remission and clinical and demographic characteristics including early symptomatic response evaluated by Positive and Negative Syndrome Scale (PANSS) at week one.Results: One hundred out of 428 patients showed social functional remission at the end of the observation period. Shorter duration of illness, higher baseline score of supervision evaluated by IEQ and higher baseline PSP were significantly associated with the social functional remission. Improvement of positive subscale of PANSS at one week was significantly associated with later social functional remission when baseline PSP scores were excluded from predictive variables.Conclusion: Shorter duration of illness, residual type of schizophrenia, higher baseline score of supervision and higher baseline social functioning were predictors of subsequent social functional remission. Although its effect seems to be limited, early symptomatic improvement could be also was a predictor of social functional remission.Keywords: schizophrenia, social function, functional outcome, long-acting injectable antipsychotics; LAI |
| first_indexed | 2024-12-13T16:37:07Z |
| format | Article |
| id | doaj.art-84d177e2918d459cb0f96654651b1332 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-13T16:37:07Z |
| publishDate | 2021-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-84d177e2918d459cb0f96654651b13322022-12-21T23:38:22ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212021-04-01Volume 171095110463976Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with SchizophreniaOhnishi TWakamatsu AKobayashi HTakashi Ohnishi,1 Akihide Wakamatsu,1 Hisanori Kobayashi2 1Medical Affairs Division, Janssen Pharmaceutical K.K., Tokyo, Japan; 2Research and Development Clinical Science Division, Janssen Pharmaceutical K.K., Tokyo, JapanCorrespondence: Takashi OhnishiMedical Affairs Division, Janssen Pharmaceutical K.K., 5-2, Nishi-kanda 3-chome Chiyoda-ku, Tokyo, 101-0065, JapanTel +81-3-4411-7700Fax +81-3-4411– 5031Email tohnish8@its.jnj.comPurpose: The aim of this study was to clarify whether early symptomatic improvement in response to a long-acting injectable antipsychotic (LAI) contributes to subsequent social functional remission in patients with schizophrenia using the previous clinical trial data (EudraCT registration number: 2011-004889-15). Associations between other factors and social functional remission were also explored.Patients and Methods: We analyzed 428 patients with schizophrenia in which the personal and social performance scale (PSP) and the involvement evaluation questionnaire (IEQ) at the time of the base line were recorded. Social functional remission was defined as participants who scored PSP > 70 at the end of 65 weeks. Logistic regression analyses were done to examine associations between social functional remission and clinical and demographic characteristics including early symptomatic response evaluated by Positive and Negative Syndrome Scale (PANSS) at week one.Results: One hundred out of 428 patients showed social functional remission at the end of the observation period. Shorter duration of illness, higher baseline score of supervision evaluated by IEQ and higher baseline PSP were significantly associated with the social functional remission. Improvement of positive subscale of PANSS at one week was significantly associated with later social functional remission when baseline PSP scores were excluded from predictive variables.Conclusion: Shorter duration of illness, residual type of schizophrenia, higher baseline score of supervision and higher baseline social functioning were predictors of subsequent social functional remission. Although its effect seems to be limited, early symptomatic improvement could be also was a predictor of social functional remission.Keywords: schizophrenia, social function, functional outcome, long-acting injectable antipsychotics; LAIhttps://www.dovepress.com/early-improvement-of-psychiatric-symptoms-with-long-acting-injectable--peer-reviewed-article-NDTschizophreniasocial functionfunctional outcomelong-acting injectable antipsychotics |
| spellingShingle | Ohnishi T Wakamatsu A Kobayashi H Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia Neuropsychiatric Disease and Treatment schizophrenia social function functional outcome long-acting injectable antipsychotics |
| title | Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia |
| title_full | Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia |
| title_fullStr | Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia |
| title_full_unstemmed | Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia |
| title_short | Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia |
| title_sort | early improvement of psychiatric symptoms with long acting injectable antipsychotic predicts subsequent social functional remission in patients with schizophrenia |
| topic | schizophrenia social function functional outcome long-acting injectable antipsychotics |
| url | https://www.dovepress.com/early-improvement-of-psychiatric-symptoms-with-long-acting-injectable--peer-reviewed-article-NDT |
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