Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study
Abstract Background Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, a...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-018-1016-5 |
| _version_ | 1818650655917604864 |
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| author | Shu-yang Yu Chen-jie Cao Li-jun Zuo Ze-jie Chen Teng-hong Lian Fang Wang Yang Hu Ying-shan Piao Li-xia Li Peng Guo Li Liu Qiu-jin Yu Rui-dan Wang Piu Chan Sheng-di Chen Xiao-min Wang Wei Zhang |
| author_facet | Shu-yang Yu Chen-jie Cao Li-jun Zuo Ze-jie Chen Teng-hong Lian Fang Wang Yang Hu Ying-shan Piao Li-xia Li Peng Guo Li Liu Qiu-jin Yu Rui-dan Wang Piu Chan Sheng-di Chen Xiao-min Wang Wei Zhang |
| author_sort | Shu-yang Yu |
| collection | DOAJ |
| description | Abstract Background Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of SN hyper echogenicity is unclear. Methods PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group. Motor symptoms (MS) and non-motor symptoms (NMS) were evaluated, and the levels of iron and related proteins in serum and cerebrospinal fluid (CSF) were detected for PD patients. Data comparison between the two groups and correlation analyses were performed. Results PDSN+ group was significantly older, and had significantly older age of onset, more advanced Hohen-Yahr stage, higher SCOPA-AUT score and lower MoCA score than PDSN- group (P < 0.05). Compared with PDSN- group, the levels of transferrin and light-ferritin in serum and iron level in CSF were significantly elevated (P < 0.05), but ferroportin level in CSF was significantly decreased in PDSN+ group (P < 0.05). Conclusions PD patients with hyper echogenicity in SN are older, at more advanced disease stage, have severer motor symptoms, and non-motor symptoms of cognitive impairment and autonomic dysfunction. Hyper echogenicity of SN in PD patients is related to dysfunction of iron metabolism, involving increased iron transport from peripheral system to central nervous system, reduction of intracellular iron release and excessive iron deposition in brain. |
| first_indexed | 2024-12-17T01:53:41Z |
| format | Article |
| id | doaj.art-84d20690cc8646f9891984a2e1612f82 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-17T01:53:41Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-84d20690cc8646f9891984a2e1612f822022-12-21T22:07:59ZengBMCBMC Neurology1471-23772018-01-011811810.1186/s12883-018-1016-5Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional studyShu-yang Yu0Chen-jie Cao1Li-jun Zuo2Ze-jie Chen3Teng-hong Lian4Fang Wang5Yang Hu6Ying-shan Piao7Li-xia Li8Peng Guo9Li Liu10Qiu-jin Yu11Rui-dan Wang12Piu Chan13Sheng-di Chen14Xiao-min Wang15Wei Zhang16Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurobiology, Beijing Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineCenter of Parkinson Disease, Beijing Institute for Brain DisordersDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of SN hyper echogenicity is unclear. Methods PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group. Motor symptoms (MS) and non-motor symptoms (NMS) were evaluated, and the levels of iron and related proteins in serum and cerebrospinal fluid (CSF) were detected for PD patients. Data comparison between the two groups and correlation analyses were performed. Results PDSN+ group was significantly older, and had significantly older age of onset, more advanced Hohen-Yahr stage, higher SCOPA-AUT score and lower MoCA score than PDSN- group (P < 0.05). Compared with PDSN- group, the levels of transferrin and light-ferritin in serum and iron level in CSF were significantly elevated (P < 0.05), but ferroportin level in CSF was significantly decreased in PDSN+ group (P < 0.05). Conclusions PD patients with hyper echogenicity in SN are older, at more advanced disease stage, have severer motor symptoms, and non-motor symptoms of cognitive impairment and autonomic dysfunction. Hyper echogenicity of SN in PD patients is related to dysfunction of iron metabolism, involving increased iron transport from peripheral system to central nervous system, reduction of intracellular iron release and excessive iron deposition in brain.http://link.springer.com/article/10.1186/s12883-018-1016-5Parkinson diseaseTranscranial sonographyHyper echogenicity in substantia nigraDysfunction of iron metabolism |
| spellingShingle | Shu-yang Yu Chen-jie Cao Li-jun Zuo Ze-jie Chen Teng-hong Lian Fang Wang Yang Hu Ying-shan Piao Li-xia Li Peng Guo Li Liu Qiu-jin Yu Rui-dan Wang Piu Chan Sheng-di Chen Xiao-min Wang Wei Zhang Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study BMC Neurology Parkinson disease Transcranial sonography Hyper echogenicity in substantia nigra Dysfunction of iron metabolism |
| title | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study |
| title_full | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study |
| title_fullStr | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study |
| title_full_unstemmed | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study |
| title_short | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study |
| title_sort | clinical features and dysfunctions of iron metabolism in parkinson disease patients with hyper echogenicity in substantia nigra a cross sectional study |
| topic | Parkinson disease Transcranial sonography Hyper echogenicity in substantia nigra Dysfunction of iron metabolism |
| url | http://link.springer.com/article/10.1186/s12883-018-1016-5 |
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